DGI:Opportunistische Infektionen/Invasive Aspergillose/Prävention und Prophylaxe - Revision history

imported>Bestem: Bestem verschob die Seite DGI:Invasive Aspergillose/Prävention und Prophylaxe nach DGI:Opportunistische Infektionen/Invasive Aspergillose/Prävention und Prophylaxe

2021-11-24T07:15:24Z

Bestem verschob die Seite DGI:Invasive Aspergillose/Prävention und Prophylaxe nach DGI:Opportunistische Infektionen/Invasive Aspergillose/Prävention und Prophylaxe

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	== Prophylaxe / Prävention ==		==Prophylaxe / Prävention==
	Patienten, die ein erhöhtes Risiko für eine invasive Aspergillose haben, sollen nach mehreren Leitlinien eine Primärprophylaxe mit einem ''Aspergillus''<span style="color: rgb(51, 51, 51)">-wirksamen Antimykotikum erhalten.</span><sup id="cite_ref-1" class="reference" style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; text-decoration: none; font-weight: 400; unicode-bidi: isolate; white-space: nowrap; color: rgb(51, 51, ~~51); font-family: "Open Sans"~~, ~~Roboto~~, ~~arial~~, ~~sans-serif; font-style~~: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; ~~background-color: rgb~~(~~255, 255, 255~~)~~;">[[DGI~~:~~Invasive Aspergillose/Prophylaxe Prävention#cite%20note~~-~~1\|[1]]]~~</~~sup~~><sup id="cite_ref-2" class="reference" style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; text-decoration: none; font-weight: 400; unicode-bidi: isolate; white-space: nowrap; color: rgb(51, 51, 51); font-family: "Open Sans", ~~Roboto~~, ~~arial~~, ~~sans-serif; font-style~~: ~~normal~~; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(~~255, 255, 255~~)~~;">[[DGI~~:~~Invasive Aspergillose/Prophylaxe Prävention#cite%20note~~-~~2\|[2]]]~~</~~sup~~><sup id="cite_ref-3" class="reference" style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; text-decoration: none; font-weight: 400; unicode-bidi: isolate; white-space: nowrap; color: rgb(51, 51, 51); font-family: "Open Sans", ~~Roboto~~, ~~arial~~, ~~sans-serif; font-style~~: ~~normal; font~~-~~variant~~-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; ~~background-color: rgb~~(~~255, 255, 255~~)~~;">[[DGI~~:~~Invasive Aspergillose/Prophylaxe Prävention#cite%20note~~-~~3\|[3]]]~~</~~sup~~><sup id="cite_ref-4" class="reference" style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; text-decoration: none; font-weight: 400; unicode-bidi: isolate; white-space: nowrap; color: rgb(51, 51, ~~51); font-family: "Open Sans"~~, Roboto, arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; ~~background-color: rgb~~(~~255, 255, 255~~)~~;">[[DGI~~:~~Invasive Aspergillose/Prophylaxe Prävention#cite%20note~~-~~4\|[4]]]~~</~~sup~~><sup id="cite_ref-5" class="reference" style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; text-decoration: none; font-weight: 400; unicode-bidi: isolate; white-space: nowrap; color: rgb(51, 51, 51); font-family: "Open Sans", ~~Roboto~~, ~~arial~~, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255);">[[DGI:Invasive Aspergillose/Prophylaxe Prävention#cite%20note-5\|[5]]]</sup><sup style="box-sizing: inherit; font-size: 13.~~2px; line-height: 1; position: relative; vertical-align: baseline; top~~: -0.~~5em~~; ~~color: rgb~~(~~51, 51, 51~~); font-family: "Open Sans", Roboto, arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: ~~0px; background~~-~~color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><span style="box-sizing: inherit;">34,48-51</span>~~</~~sup~~> <span style="color: rgb(51, 51, 51)">Dies wird nach der Anzahl der Tage zu erwartender Neutropenie gesteuert. Generell ist eine antimykotische Prophylaxe bei Patienten, die < 7 Tage neutropenisch sind, nicht erforderlich. Patienten mit AML, MDS oder mit GvHD nach allogener Stammzelltransplantation sollten eine Posaconazol-Prophylaxe erhalten.</span><sup id="cite_ref-6" class="reference" style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; text-decoration: none; font-weight: 400; unicode-bidi: isolate; white-space: nowrap; color: rgb(51, 51, 51); font-family: "Open Sans", ~~Roboto~~, ~~arial~~, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; ~~background-color: rgb~~(~~255, 255, 255~~)~~;">[[DGI~~:~~Invasive Aspergillose/Prophylaxe Prävention#cite%20note~~-~~6\|[6]]]~~</~~sup~~><sup id="cite_ref-7" class="reference" style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; text-decoration: none; font-weight: 400; unicode-bidi: isolate; white-space: nowrap; color: rgb(51, 51, 51); font-family: "Open Sans", Roboto, arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, ~~255~~, ~~255);">[[DGI:Invasive Aspergillose/Prophylaxe Prävention#cite%20note-7\|[7]]]</sup><sup style="box-sizing: inherit; font-size: 13~~.~~2px; line-height: 1; position: relative; vertical~~-~~align: baseline; top:~~ -0.~~5em~~; ~~color: rgb~~(~~51, 51, 51~~)~~; font-family: "Open Sans", Roboto, arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans~~: ~~2; text~~-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><span style="box-sizing: inherit;">52,53</span></~~sup~~>		Patienten, die ein erhöhtes Risiko für eine invasive Aspergillose haben, sollen nach mehreren Leitlinien eine Primärprophylaxe mit einem ''Aspergillus''<span style="color: rgb(51, 51, 51)">-wirksamen Antimykotikum erhalten.</span><ref>Patterson TF, Thompson GR, 3rd, Denning DW, et al. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis 2016; 63(4): e1-e60</ref><ref>Freifeld AG, Bow EJ, Sepkowitz KA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america. Clin Infect Dis 2011; 52(4): e56-93</ref><ref>Maertens J, Marchetti O, Herbrecht R, et al. European guidelines for antifungal management in leukemia and hematopoietic stem cell transplant recipients: summary of the ECIL 3--2009 update. Bone marrow transplantation 2011; 46(5): 709-18</ref><ref>Tacke D, Buchheidt D, Karthaus M, et al. Primary prophylaxis of invasive fungal infections in patients with haematologic malignancies. 2014 update of the recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology. Annals of hematology 2014; 93(9): 1449-56</ref><ref>Tomblyn M, Chiller T, Einsele H, et al. Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective. Biol Blood Marrow Transplant 2009; 15(10): 1143-238</ref><span style="color: rgb(51, 51, 51)">Dies wird nach der Anzahl der Tage zu erwartender Neutropenie gesteuert. Generell ist eine antimykotische Prophylaxe bei Patienten, die < 7 Tage neutropenisch sind, nicht erforderlich. Patienten mit AML, MDS oder mit GvHD nach allogener Stammzelltransplantation sollten eine Posaconazol-Prophylaxe erhalten.</span><ref>Cornely OA, Maertens J, Winston DJ, et al. Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia. N Engl J Med 2007; 356(4): 348-59</ref><ref>Ullmann AJ, Lipton JH, Vesole DH, et al. Posaconazole or fluconazole for prophylaxis in severe graft-versus-host disease. N Engl J Med 2007; 356(4): 335-47</ref>

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2021-09-27T13:11:07Z

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== Prophylaxe / Prävention ==
Patienten, die ein erhöhtes Risiko für eine invasive Aspergillose haben, sollen nach mehreren Leitlinien eine Primärprophylaxe mit einem ''Aspergillus''-wirksamen Antimykotikum erhalten.<sup id="cite_ref-1" class="reference" style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; text-decoration: none; font-weight: 400; unicode-bidi: isolate; white-space: nowrap; color: rgb(51, 51, 51); font-family: "Open Sans", Roboto, arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255);">[[DGI:Invasive Aspergillose/Prophylaxe Prävention#cite%20note-1|[1]]]<sup id="cite_ref-2" class="reference" style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; text-decoration: none; font-weight: 400; unicode-bidi: isolate; white-space: nowrap; color: rgb(51, 51, 51); font-family: "Open Sans", Roboto, arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255);">[[DGI:Invasive Aspergillose/Prophylaxe Prävention#cite%20note-2|[2]]]<sup id="cite_ref-3" class="reference" style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; text-decoration: none; font-weight: 400; unicode-bidi: isolate; white-space: nowrap; color: rgb(51, 51, 51); font-family: "Open Sans", Roboto, arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255);">[[DGI:Invasive Aspergillose/Prophylaxe Prävention#cite%20note-3|[3]]]<sup id="cite_ref-4" class="reference" style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; text-decoration: none; font-weight: 400; unicode-bidi: isolate; white-space: nowrap; color: rgb(51, 51, 51); font-family: "Open Sans", Roboto, arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255);">[[DGI:Invasive Aspergillose/Prophylaxe Prävention#cite%20note-4|[4]]]<sup id="cite_ref-5" class="reference" style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; text-decoration: none; font-weight: 400; unicode-bidi: isolate; white-space: nowrap; color: rgb(51, 51, 51); font-family: "Open Sans", Roboto, arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255);">[[DGI:Invasive Aspergillose/Prophylaxe Prävention#cite%20note-5|[5]]]<sup style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; color: rgb(51, 51, 51); font-family: "Open Sans", Roboto, arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">34,48-51 Dies wird nach der Anzahl der Tage zu erwartender Neutropenie gesteuert. Generell ist eine antimykotische Prophylaxe bei Patienten, die < 7 Tage neutropenisch sind, nicht erforderlich. Patienten mit AML, MDS oder mit GvHD nach allogener Stammzelltransplantation sollten eine Posaconazol-Prophylaxe erhalten.<sup id="cite_ref-6" class="reference" style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; text-decoration: none; font-weight: 400; unicode-bidi: isolate; white-space: nowrap; color: rgb(51, 51, 51); font-family: "Open Sans", Roboto, arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255);">[[DGI:Invasive Aspergillose/Prophylaxe Prävention#cite%20note-6|[6]]]<sup id="cite_ref-7" class="reference" style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; text-decoration: none; font-weight: 400; unicode-bidi: isolate; white-space: nowrap; color: rgb(51, 51, 51); font-family: "Open Sans", Roboto, arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255);">[[DGI:Invasive Aspergillose/Prophylaxe Prävention#cite%20note-7|[7]]]<sup style="box-sizing: inherit; font-size: 13.2px; line-height: 1; position: relative; vertical-align: baseline; top: -0.5em; color: rgb(51, 51, 51); font-family: "Open Sans", Roboto, arial, sans-serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">52,53