DGI:ZNS-Infektionen/Nosokomiale Ventrikulitis und Meningitis/Therapie: Difference between revisions

Latest revision as of 08:34, 14 September 2021

Die Fokussanierung steht im Vordergrund, infizierte Kathetersysteme sollten entfernt werden. Begleitend erfolgt eine antibiotische Therapie, die zunächst hauptsächlich auf gram-positive Kokken zielt, begleitend sind Enterobacterales und Pseudomonas spp. zu erfassen. Es sollte bei Erregernachweis eine Deeskalation nach Antibiogramm erfolgen. Die Therapiedauer beträgt i.d.R. 10-14 Tage.

Dosierungsempfehlungen antiinfektiver Therapien

Intravenöse Applikation ^[1]^[2]
Antibiotikum	Tagesdosis (Beispiel)	Bemerkung
Aztreonam	6-8g (3-4x 2g)
Cefepim	6g (3x 2g)	CI, PI
Cefotaxim	12g (6x 2g)
Ceftazidim	6g (3x 2g)	CI, PI, TDM
Ceftriaxon	4g (2x 2g)
Ciprofloxacin	1200mg (3x 400mg)
Flucloxacillin	12g (6x 2g)	TDM
Fluconazol	800mg (1x tgl.)
Fosfomycin	24g (3x 8g)
Linezolid	1200mg (2x 600mg)	CI, TDM
Liposomales Amphotericin B	2-5 mg/kg (1x tgl.)
Meropenem	6g (3x 2g)	CI, PI, TDM
Posaconazol	800mg (2x 400mg)	TDM
Rifampicin	600-1200mg (1-2x tgl.)
Vancomycin	30-60 mg/kg (2-4x tgl.)	CI, TDM
Voriconazol	8 mg/kg (2x tgl.)	TDM

Intrathekale Applikation ^[1]^[3]
Antibiotikum	Tagesdosis (1xtgl.)	Bemerkung
Gentamicin	4-10mg
Tobramycin	5-10mg
Amikacin	30mg
Colistin	10mg
Daptomycin	5-10mg
Vancomycin	10-20mg
Tigecyclin	1-10mg
Caspofungin	5-10mg

↑ ^1.0 ^1.1 Tunkel AR, Hasbun R, Bhimraj A, Byers K, Kaplan SL, Michael Scheld W, van de Beek D, Bleck TP, Garton HJ, Zunt JR: 2017 Infectious Diseases Society of America's Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis. Clin Infect Dis 2017; 64: e34–e65
↑ Ambulant erworbene bakterielle (eitrige) Meningoenzephalitis im Erwachsenenalter, AWMF-Registernummer: 030/089 [https://www.awmf.org/leitlinien/detail/ll/030-089.html
↑ Nau R, Blei C, Eiffert H: Intrathecal Antibacterial and Antifungal Therapies. Clin Microbiol Rev 2020; 33(3)

[:b0-1] 1.0 ^1.1 Tunkel AR, Hasbun R, Bhimraj A, Byers K, Kaplan SL, Michael Scheld W, van de Beek D, Bleck TP, Garton HJ, Zunt JR: 2017 Infectious Diseases Society of America's Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis. Clin Infect Dis 2017; 64: e34–e65

[:1-2] Ambulant erworbene bakterielle (eitrige) Meningoenzephalitis im Erwachsenenalter, AWMF-Registernummer: 030/089 [https://www.awmf.org/leitlinien/detail/ll/030-089.html

[3] Nau R, Blei C, Eiffert H: Intrathecal Antibacterial and Antifungal Therapies. Clin Microbiol Rev 2020; 33(3)

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-==Therapie==
+Die Fokussanierung steht im Vordergrund, infizierte Kathetersysteme sollten entfernt werden. Begleitend erfolgt eine antibiotische Therapie, die zunächst hauptsächlich auf gram-positive Kokken zielt, begleitend sind Enterobacterales und ''Pseudomonas'' ''spp''. zu erfassen. Es sollte bei Erregernachweis eine Deeskalation nach Antibiogramm erfolgen. Die Therapiedauer beträgt i.d.R. 10-14 Tage.
-<span class="ve-pasteProtect" style="font-size:12.0pt;
-mso-fareast-font-family:&quot;Times New Roman&quot;;mso-bidi-font-family:Calibri;
-mso-bidi-theme-font:minor-latin;mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;font-size:12.0pt;\nmso-fareast-font-family:\&quot;Times New Roman\&quot;;mso-bidi-font-family:Calibri;\nmso-bidi-theme-font:minor-latin;mso-ansi-language:DE&quot;}">Die Fokussanierung steht im Vordergrund, infizierte Kathetersysteme sollten entfernt werden. Begleitend erfolgt eine antibiotische Therapie, die zunächst hauptsächlich auf gram-positive Kokken zielt, begleitend sind Enterobacterales und Pseudomonas spp. zu erfassen. Es sollte bei Erregernachweis eine Deeskalation nach Antibiogramm erfolgen. Die Therapiedauer beträgt i.d.R. 10-14 Tage.</span>
-=====<span class="ve-pasteProtect" style="font-size:13.5pt; mso-fareast-font-family:&quot;Times New Roman&quot;;mso-bidi-font-family:Calibri; mso-bidi-theme-font:minor-latin;mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;font-size:13.5pt;\nmso-fareast-font-family:\&quot;Times New Roman\&quot;;mso-bidi-font-family:Calibri;\nmso-bidi-theme-font:minor-latin;mso-ansi-language:DE&quot;}">Dosierungsempfehlungen antibiotischer Therapien</span>=====
+=====Dosierungsempfehlungen antiinfektiver Therapien=====
-'''<span class="ve-pasteProtect" style="mso-ansi-language:
+<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}"><span class="ve-pasteProtect" style="mso-no-proof:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-no-proof:yes&quot;}"></span></span><span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}"><span class="ve-pasteProtect" style="mso-no-proof:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-no-proof:yes&quot;}"></span></span><span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}"><span class="ve-pasteProtect" style="mso-no-proof:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-no-proof:yes&quot;}"></span></span>
-DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:\nDE&quot;}">intravenöse Applikation </span><span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}"><span class="ve-pasteProtect" style="mso-no-proof:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-no-proof:yes&quot;}">[28, 31]</span></span>'''
+{| class="wikitable "
-{| class="MsoTable15List1Light" border="0" cellspacing="0" cellpadding="0" style="border-collapse:collapse;mso-yfti-tbllook:1184;mso-padding-alt:5.65pt 5.4pt 5.65pt 5.4pt" data-ve-attributes="{&quot;style&quot;:&quot;border-collapse:collapse;mso-yfti-tbllook:1184;mso-padding-alt:5.65pt 5.4pt 5.65pt 5.4pt&quot;}"
+|+
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |'''Antibiotikum'''
+Intravenöse Applikation <ref name=":b0"><span style="color: #333333">Tunkel AR, Hasbun R, Bhimraj A, Byers K, Kaplan SL, Michael Scheld W, van de Beek D, Bleck TP, Garton HJ, Zunt JR: 2017 Infectious Diseases Society of America's Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis. Clin Infect Dis 2017; 64: e34–e65</span></ref><ref name=":1"><span class="ve-pasteprotect">Ambulant erworbene bakterielle (eitrige) Meningoenzephalitis im Erwachsenenalter, AWMF-Registernummer: 030/089 [</span><span style="color: #333333">https://www.awmf.org/leitlinien/detail/ll/030-089.html</span><span data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}" style="box-sizing: inherit"><span class="ve-pasteprotect"></span></span></ref>
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |'''Tagesdosis (Beispiel)'''
+!Antibiotikum
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |'''Bemerkung'''
+!Tagesdosis (Beispiel)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |'''Anpassung'''
+!Bemerkung
-|- style="mso-yfti-irow:0" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:0&quot;}"
+!Anpassung
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |Aztreonam
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |6-8g (3-4x  2g)
+|Aztreonam
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |
+|6-8g (3-4x 2g)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|
-|- style="mso-yfti-irow:1" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:1&quot;}"
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">Cefepim</span>
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">6g (3x 2g)</span>
+|Cefepim
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">CI, PI</span>
+|6g (3x 2g)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|CI, PI
-|- style="mso-yfti-irow:2" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:2&quot;}"
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |Cefotaxim
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |<span class="ve-pasteProtect" style="color: black" data-ve-attributes="{&quot;style&quot;:&quot;color: black&quot;}">12g  (6x 2g)</span>
+|Cefotaxim
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |
+|12g (6x 2g)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|
-|- style="mso-yfti-irow:3" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:3&quot;}"
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |Ceftazidim
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">6g (3x 2g)</span>
+|Ceftazidim
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">CI, PI, TDM</span>
+|6g (3x 2g)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|CI, PI, TDM
-|- style="mso-yfti-irow:4" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:4&quot;}"
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |Ceftriaxon
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |4g (2x 2g)
+|Ceftriaxon
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |
+|4g (2x 2g)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|
-|- style="mso-yfti-irow:5" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:5&quot;}"
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |Ciprofloxacin
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |1200mg (3x 400mg)
+|Ciprofloxacin
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |
+|1200mg (3x 400mg)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|
-|- style="mso-yfti-irow:6" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:6&quot;}"
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |Flucloxacillin
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |12g (6x 2g)
+|Flucloxacillin
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |TDM
+|12g (6x 2g)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|TDM
-|- style="mso-yfti-irow:7" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:7&quot;}"
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |Fluconazol
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |800mg (1x tgl.)
+|Fluconazol
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |
+|800mg (1x tgl.)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|
-|- style="mso-yfti-irow:8" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:8&quot;}"
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |Fosfomycin
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |24g (3x 8g)
+|Fosfomycin
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |
+|24g (3x 8g)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|
-|- style="mso-yfti-irow:9" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:9&quot;}"
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |Linezolid
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |1200mg (2x 600mg)
+|Linezolid
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |CI, TDM
+|1200mg (2x 600mg)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|CI, TDM
-|- style="mso-yfti-irow:10" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:10&quot;}"
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |liposomales  Amphotericin B
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |2-5 mg/kg  (1x tgl.)
+|Liposomales Amphotericin B
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |
+|2-5 mg/kg (1x tgl.)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|
-|- style="mso-yfti-irow:11" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:11&quot;}"
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |Meropenem
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |6g (3x 2g)
+|Meropenem
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |CI, PI, TDM
+|6g (3x 2g)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|CI, PI, TDM
-|- style="mso-yfti-irow:12" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:12&quot;}"
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |Posaconazol
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |800mg (2x  400mg)
+|Posaconazol
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |TDM
+|800mg (2x 400mg)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|TDM
-|- style="mso-yfti-irow:13" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:13&quot;}"
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |Rifampicin
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |600-1200mg (1-2x tgl.)
+|Rifampicin
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |
+|600-1200mg (1-2x tgl.)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|
-|- style="mso-yfti-irow:14" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:14&quot;}"
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |Vancomycin
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |30-60 mg/kg  (2-4x tgl.)
+|Vancomycin
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |CI, TDM
+|30-60 mg/kg (2-4x tgl.)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|CI, TDM
-|- style="mso-yfti-irow:15;mso-yfti-lastrow:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:15;mso-yfti-lastrow:yes&quot;}"
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;" width="163" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:122.35pt;&quot;}" |Voriconazol
+|-
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;" width="155" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:116.45pt;&quot;}" |8 mg/kg (2x tgl.)
+|Voriconazol
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;" width="116" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:87.25pt;&quot;}" |TDM
+|8 mg/kg (2x tgl.)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;" width="170" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:127.55pt;&quot;}" |
+|TDM
-|}Legende:
+|
+|}
-CI: kontinuierliche Infusion (engl. continuous infusion)
+<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}"><span class="ve-pasteProtect" style="mso-no-proof:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-no-proof:yes&quot;}"></span></span><span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}"><span class="ve-pasteProtect" style="mso-no-proof:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-no-proof:yes&quot;}"></span></span><span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}"><span class="ve-pasteProtect" style="mso-no-proof:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-no-proof:yes&quot;}"></span></span>
+{| class="wikitable "
-PI: prolongierte Infusion (engl. prolonged infusion)
+|+
+<span class="ve-pasteProtect" style="mso-ansi-language:
-TDM: Therapeutisches Drug Monitoring (engl. therapeutic drug monitoring)
+DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:\nDE&quot;}">Intrathekale Applikation </span><ref name=":b0" /><ref><span style="color: #333333">Nau R, Blei C, Eiffert H: Intrathecal Antibacterial and Antifungal Therapies. Clin Microbiol Rev 2020; 33(3)</span></ref>
+!Antibiotikum
+!Tagesdosis (1xtgl.)
-'''<span class="ve-pasteProtect" style="mso-ansi-language:
+!Bemerkung
-DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:\nDE&quot;}">intrathekale Applikation </span><span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}"><span class="ve-pasteProtect" style="mso-no-proof:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-no-proof:yes&quot;}">[28, 32]</span></span>'''
+|-
-{| class="MsoTable15List1Light" border="0" cellspacing="0" cellpadding="0" style="border-collapse:collapse;mso-yfti-tbllook:1184;mso-padding-alt:5.65pt 5.4pt 5.65pt 5.4pt" data-ve-attributes="{&quot;style&quot;:&quot;border-collapse:collapse;mso-yfti-tbllook:1184;mso-padding-alt:5.65pt 5.4pt 5.65pt 5.4pt&quot;}"
+|Gentamicin
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |'''Antibiotikum'''
+|4-10mg
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |'''Tagesdosis (1x tgl.)'''
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |'''Bemerkung'''
+|-
-|- style="mso-yfti-irow:0" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:0&quot;}"
+|Tobramycin
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Gentamicin
+|5-10mg
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |4-10mg
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |
+|-
-|- style="mso-yfti-irow:1" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:1&quot;}"
+|Amikacin
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">Tobramycin</span>
+|30mg
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">5-10mg</span>
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |
+|-
-|- style="mso-yfti-irow:2" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:2&quot;}"
+|Colistin
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Amikacin
+|10mg
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |<span class="ve-pasteProtect" style="color: black" data-ve-attributes="{&quot;style&quot;:&quot;color: black&quot;}">30mg</span>
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |
+|-
-|- style="mso-yfti-irow:3" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:3&quot;}"
+|Daptomycin
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Colistin
+|5-10mg
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">10mg</span>
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |
+|-
-|- style="mso-yfti-irow:4" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:4&quot;}"
+|Vancomycin
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Daptomycin
+|10-20mg
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |<span class="ve-pasteProtect" style="color: black" data-ve-attributes="{&quot;style&quot;:&quot;color: black&quot;}">5-10mg</span>
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |
+|-
-|- style="mso-yfti-irow:5" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:5&quot;}"
+|Tigecyclin
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Vancomycin
+|1-10mg
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">10-20mg</span>
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |
+|-
-|- style="mso-yfti-irow:6" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:6&quot;}"
+|Caspofungin
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Tigecyclin
+|5-10mg
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |<span class="ve-pasteProtect" style="color: black" data-ve-attributes="{&quot;style&quot;:&quot;color: black&quot;}">1-10mg</span>
+|
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |
+|}
-|- style="mso-yfti-irow:7;mso-yfti-lastrow:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:7;mso-yfti-lastrow:yes&quot;}"
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Caspofungin
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">5-10mg</span>
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |
-|}<br />
-===<span class="ve-pasteProtect" style="font-size:13.5pt; mso-fareast-font-family:&quot;Times New Roman&quot;;mso-bidi-font-family:Calibri; mso-bidi-theme-font:minor-latin;mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;font-size:13.5pt;\nmso-fareast-font-family:\&quot;Times New Roman\&quot;;mso-bidi-font-family:Calibri;\nmso-bidi-theme-font:minor-latin;mso-ansi-language:DE&quot;}">Kalkulierte Therapie</span> <span class="ve-pasteProtect" style="font-size:13.5pt;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-bidi-font-family: Calibri;mso-bidi-theme-font:minor-latin;mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;font-size:13.5pt;mso-fareast-font-family:\&quot;Times New Roman\&quot;;mso-bidi-font-family:\nCalibri;mso-bidi-theme-font:minor-latin;mso-ansi-language:DE&quot;}"><span class="ve-pasteProtect" style="mso-no-proof:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-no-proof:yes&quot;}">[28, 31]</span></span>===
-<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">Vancomycin PLUS Meropenem</span>
-<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">Alternative Meropenem: Ceftazidim oder Cefepim (im Falle eines operativen Zugangs durch Schleimhäute PLUS Metronidazol)</span>
-<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">Alternative Vancomycin: Linezolid (cave: bakteriostatisch)</span>
-<br />
-===<span class="ve-pasteProtect" style="font-size:13.5pt; mso-fareast-font-family:&quot;Times New Roman&quot;;mso-bidi-font-family:Calibri; mso-bidi-theme-font:minor-latin;mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;font-size:13.5pt;\nmso-fareast-font-family:\&quot;Times New Roman\&quot;;mso-bidi-font-family:Calibri;\nmso-bidi-theme-font:minor-latin;mso-ansi-language:DE&quot;}">Erregerspezifische Therapie</span> <span class="ve-pasteProtect" style="font-size:13.5pt;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-bidi-font-family: Calibri;mso-bidi-theme-font:minor-latin;mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;font-size:13.5pt;mso-fareast-font-family:\&quot;Times New Roman\&quot;;mso-bidi-font-family:\nCalibri;mso-bidi-theme-font:minor-latin;mso-ansi-language:DE&quot;}"><span class="ve-pasteProtect" style="mso-no-proof:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-no-proof:yes&quot;}">[28, 31]</span></span>===
-{| class="MsoTable15List1Light" border="0" cellspacing="0" cellpadding="0" style="border-collapse:collapse;mso-yfti-tbllook:1184;mso-padding-alt:5.65pt 5.4pt 5.65pt 5.4pt" data-ve-attributes="{&quot;style&quot;:&quot;border-collapse:collapse;mso-yfti-tbllook:1184;mso-padding-alt:5.65pt 5.4pt 5.65pt 5.4pt&quot;}"
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |'''Erreger'''
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |'''Standardtherapie'''
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |'''Alternativtherapie'''
-|- style="mso-yfti-irow:0" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:0&quot;}"
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Enterobacterales (z.B. ''Klebsiella ''spp., ''E. coli''<span class="ve-pasteProtect" style="mso-bidi-font-style:italic" data-ve-attributes="{&quot;style&quot;:&quot;mso-bidi-font-style:italic&quot;}">)</span>
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Cefotaxim/Ceftriaxon
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Cefepim,  Meropenem, Ciprofloxacin
-|- style="mso-yfti-irow:1" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:1&quot;}"
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">Enterobacterales mit induzierbaren  AmpC-Betalactamasen (z.B. ''Enterobacter cloacae'') oder ESBL-Bildner</span>
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">Meropenem</span>
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Ciprofloxacin
-|- style="mso-yfti-irow:2" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:2&quot;}"
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |''Pseudomonas  aeruginosa ''
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |<span class="ve-pasteProtect" style="color: black" data-ve-attributes="{&quot;style&quot;:&quot;color: black&quot;}">Ceftazidim,  Meropenem, Cefepim, ggf. jeweils in Kombination mit Fosfomycin</span><span class="ve-pasteProtect" style="color: black" data-ve-attributes="{&quot;style&quot;:&quot;color: black&quot;}">Colistin  (nur bei nachgewiesener Multiresistenz, i.v.+i.t.)</span>
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |<span class="ve-pasteProtect" style="color: black" data-ve-attributes="{&quot;style&quot;:&quot;color: black&quot;}">Aztreonam  oder</span> Ciprofloxacin
-|- style="mso-yfti-irow:3" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:3&quot;}"
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |''Acinetobacter baumanii''
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">Meropenem</span>
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |<span class="ve-pasteProtect" style="mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;mso-ansi-language:DE&quot;}">Colistin (i.v.+i.t.)</span>
-|- style="mso-yfti-irow:4" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:4&quot;}"
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |''Staphylococcus  ''spp.  (Methicillin-empfindlich)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |<span class="ve-pasteProtect" style="color: black" data-ve-attributes="{&quot;style&quot;:&quot;color: black&quot;}">Flucloxacillin</span><span class="ve-pasteProtect" style="color: black" data-ve-attributes="{&quot;style&quot;:&quot;color: black&quot;}">ggf.  PLUS Fosfomycin, Rifampicin oder Linezolid</span>
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Vancomycin
-|- style="mso-yfti-irow:5" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:5&quot;}"
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |''Staphylococcus ''spp.  (Methicillin-resistent)
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Vancomycin ggf. PLUS Fosfomycin, Rifampicin oder Linezolid
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Linezolid
-|- style="mso-yfti-irow:6" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:6&quot;}"
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |''Candida  spp.''
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |liposomales  Amphotericin B ggf. PLUS Flucytosin
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Voriconazol,  bei ''C. albicans'': Fluconazol
-|- style="mso-yfti-irow:7;mso-yfti-lastrow:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-yfti-irow:7;mso-yfti-lastrow:yes&quot;}"
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |''Aspergillus spp.''
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |Voriconazol
-| style="border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;" class="col-white-bg" width="202" valign="top" data-ve-attributes="{&quot;style&quot;:&quot;border-left-width:3px;border-right-width:3px;border-top-width:3px;border-bottom-width:3px;border-left-color:#000000;border-right-color:#000000;border-top-color:#000000;border-bottom-color:#000000;width:151.2pt;&quot;}" |liposomales Amphotericin B, Posaconazol
-|}Legende: i.v. = intravenös, i.t. = intrathekal
-<span class="ve-pasteProtect" style="font-size:12.0pt;
-line-height:107%;mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;font-size:12.0pt;\nline-height:107%;mso-ansi-language:DE&quot;}">Bei carbapenemresistenten gram-negativen Erregern sollte eine ergänzende intrathekale Therapie erfolgen. Für dieses Therapieregime konnte eine signifikante Reduktion der Sterblichkeit gezeigt werden <span class="ve-pasteProtect" style="mso-spacerun:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-spacerun:yes&quot;}"> </span></span><span class="ve-pasteProtect" style="font-size:12.0pt;line-height:107%;mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;font-size:12.0pt;line-height:107%;mso-ansi-language:DE&quot;}"><span class="ve-pasteProtect" style="mso-no-proof:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-no-proof:yes&quot;}">[</span></span><span class="ve-pasteProtect" style="font-size:12.0pt;
-line-height:107%;mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;font-size:12.0pt;\nline-height:107%;mso-ansi-language:DE&quot;}"><span class="ve-pasteProtect" style="mso-spacerun:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-spacerun:yes&quot;}">33</span></span><span class="ve-pasteProtect" style="font-size:12.0pt;line-height:107%;mso-ansi-language:DE" data-ve-attributes="{&quot;style&quot;:&quot;font-size:12.0pt;line-height:107%;mso-ansi-language:DE&quot;}"><span class="ve-pasteProtect" style="mso-no-proof:yes" data-ve-attributes="{&quot;style&quot;:&quot;mso-no-proof:yes&quot;}">]</span>. Diese Erkenntnisse konnten noch nicht in die aktuellen Leitlinien aufgenommen werden.</span>
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