DGI:Perioperative Prophylaxe/Abstract: Difference between revisions

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'''perioperative''' '''Antibiotika-Prophylaxe''' '''(PAP)'''
Die '''perioperative Antibiotikaprophylaxe''' (PAP) wird kurzzeitig bei bestimmten Eingriffen eingesetzt mit dem Ziel die postoperativen Infektionskomplikationen zu verhindern oder zu reduzieren. Es handelt sich um eine Prophylaxe, keine Therapie. Bei Vorliegen einer Infektion muss die Antibiotikagabe als Therapie weitergeführt werden und eine erneute perioperative mikrobiologische Diagnostik durchgeführt werden.
 
'''Inhaltsverzeichnis'''
 
1. <span style="mso-tab-count:1">  </span>Allgemeines<span style="mso-tab-count:1 dotted">..................................................................................................................... </span>2
 
2. <span style="mso-tab-count:1">  </span>perioperative Antibiotikaprophlyaxe<span style="mso-tab-count:1 dotted">..................................................................................... </span>4
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Chirurgische / Viszeralchirurgische Eingriffe<span style="mso-tab-count:
1 dotted">....................................................................... </span>4
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Endoskopische Eingriffe<span style="mso-tab-count:1 dotted">.................................................................................................. </span>4
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Kardio-/Gefäßchirurgische Eingriffe<span style="mso-tab-count:1 dotted">.................................................................................. </span>4
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Thoraxchirurgische Eingriffe<span style="mso-tab-count:1 dotted">............................................................................................ </span>5
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Geburtshilfe und Gynäkologische Eingriffe<span style="mso-tab-count:
1 dotted">......................................................................... </span>5
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>HNO-/MKG- Eingriffe<span style="mso-tab-count:1 dotted">................................................................................................... </span>5/6
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Neurochirurgische Eingriffe<span style="mso-tab-count:1 dotted">............................................................................................. </span>7
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Ophthalmologische Eingriffe<span style="mso-tab-count:1 dotted">............................................................................................ </span>7
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Orthopädisch-/Traumatologisch-/ Handchirurgische Eingriffe<span style="mso-tab-count:1 dotted">................................................. </span>7
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Dermatologische Eingriffe<span style="mso-tab-count:1 dotted">............................................................................................... </span>7
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Endo-Urologische Eingriffe<span style="mso-tab-count:1 dotted">.............................................................................................. </span>8
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Urologische Diagnostische Eingriffe<span style="mso-tab-count:1 dotted">.................................................................................. </span>8
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Laparoskopische Eingriffe<span style="mso-tab-count:1 dotted">............................................................................................... </span>8
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Urologische offene Eingriffe<span style="mso-tab-count:1 dotted">............................................................................................. </span>9
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>CAPD-Katheter<span style="mso-tab-count:1 dotted">............................................................................................................. </span>9
 
3. <span style="mso-tab-count:1">  </span><span style="letter-spacing:-.15pt">M</span>ulti-<span style="letter-spacing:-1.5pt"> </span><span style="letter-spacing:-.05pt">und</span><span style="letter-spacing:
-1.45pt"> </span>panr<span style="letter-spacing:-.15pt">esiste</span>nt<span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-1.45pt"> </span><span style="letter-spacing:-.2pt">Er</span><span style="letter-spacing:-.15pt">r</span><span style="letter-spacing:-.2pt">ege</span><span style="letter-spacing:-.15pt">r</span><span style="letter-spacing:-1.55pt"> </span>(MRE)<span style="letter-spacing:-1.45pt"> </span><span style="letter-spacing:-.15pt">z.B</span>.<span style="letter-spacing:
-1.45pt"> </span><span style="letter-spacing:-.15pt">MRSA</span>-,<span style="letter-spacing:-1.45pt"> </span>MRGN-Be<span style="letter-spacing:-.05pt">siedlun</span>g<span style="mso-tab-count:1 dotted">.......................................... </span>9
 
4. <span style="mso-tab-count:1">  </span>PAP bei Allergie gegen Beta-Laktam-Antibiotika<span style="letter-spacing:-1.5pt"> </span><span style="mso-tab-count:1 dotted">..................................................................... </span>9
 
5. <span style="mso-tab-count:1">  </span>Penicillin-Allergie<span style="letter-spacing:-1.5pt"> </span><span style="mso-tab-count:1 dotted">............................................................................................................ </span>10
 
6. <span style="mso-tab-count:1">  </span>Endokarditis-Prophylaxe<span style="letter-spacing:-1.5pt"> </span><span style="mso-tab-count:1 dotted">................................................................................................... </span>10
 
7. <span style="mso-tab-count:1">  </span>PAP und Endokarditis-Prophylaxe<span style="letter-spacing:-1.5pt"> </span><span style="mso-tab-count:1 dotted">....................................................................................... </span>11
 
8. <span style="mso-tab-count:1">  </span>Antibiotika für die PAP- und Endokarditis-Prophylaxe<span style="letter-spacing:-1.5pt"> </span><span style="mso-tab-count:1 dotted">............................................................. </span>12
 
<span style="mso-list:Ignore">Ø<span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Sonderindikationen<span style="letter-spacing:-1.5pt"> </span><span style="mso-tab-count:1 dotted">..................................................................................................... </span>12
 
9. <span style="mso-tab-count:1">  </span>Literatur<span style="letter-spacing:-1.5pt"> </span><span style="mso-tab-count:1 dotted">........................................................................................................................ </span>13
 
===Ziel===
Die <span style="letter-spacing:-.1pt">perioperative</span> <span style="letter-spacing:
-.05pt">Antibiotikaprophylaxe</span> <span style="letter-spacing:-.3pt">(PAP)</span> <span style="letter-spacing:.05pt">wird</span> kurzzeitig <span style="letter-spacing:-.05pt">bei</span> bestimmten <span style="letter-spacing:
.05pt">Eingriffen</span> eingesetzt, <span style="letter-spacing:-.05pt">mit</span> <span style="letter-spacing:-.05pt">dem</span><span style="letter-spacing:3.3pt"> </span><span style="letter-spacing:-.05pt">Ziel</span> die <span style="letter-spacing:-.1pt">postoperativen</span> <span style="letter-spacing:
-.05pt">Infektionskomplikationen</span> zu <span style="letter-spacing:-.05pt">verhindern</span> <span style="letter-spacing:-.05pt">oder</span> zu <span style="letter-spacing:
-.05pt">reduzieren.</span> Es <span style="letter-spacing:-.05pt">handelt</span> <span style="letter-spacing:-.05pt">sich</span> <span style="letter-spacing:
.1pt">um</span> eine <span style="letter-spacing:-.15pt">Prophylaxe,</span> keine <span style="letter-spacing:-.1pt">Therapie.</span> Bei <span style="letter-spacing:-.15pt">Vorliegen</span> einer Infektion muss die Antibiotikagabe <span style="letter-spacing:.05pt">als</span> <span style="letter-spacing:-.1pt">Therapie</span> <span style="letter-spacing:-.05pt">weitergeführt</span><span style="letter-spacing:4.25pt"> </span><span style="letter-spacing:-.1pt">werden. Bei aktiver Infektion sollten keine elektiven Operationen durchgeführt werden.</span>
 
'''Indikation:''' Die Indikation ist für alle Operationen die in dieser Handlungsempfehlung aufgelistet sind mit den Fachgruppen konsentiert und bedürfen keiner Rücksprache. Müssen Abweichungen vorgenommen werden, sind diese mit den jeweiligen Operateuren im Vorfeld abzusprechen.<span style="mso-spacerun:yes">  </span>
 
Die <span style="letter-spacing:-.05pt">Hauptindikation</span> <span style="letter-spacing:
-.1pt">der</span> <span style="letter-spacing:-.4pt">PAP</span> sind sauber-kontaminierte <span style="letter-spacing:-.25pt">bzw.</span> kontaminierte Eingriffe. Bei <span style="letter-spacing:-.05pt">den</span> <span style="letter-spacing:-.05pt">meisten</span> <span style="letter-spacing:.05pt">aseptischen</span> <span style="letter-spacing:.05pt">Eingriffen,</span> <span style="letter-spacing:
-.05pt">ausgenommen</span>
 
Implantationen <span style="letter-spacing:-.15pt">von</span> größerem <span style="letter-spacing:-.05pt">Fremdmaterial</span> <span style="letter-spacing:
.05pt">und</span> <span style="letter-spacing:.05pt">herzchirurgischen</span><span style="letter-spacing:2.4pt"> </span><span style="letter-spacing:.05pt">Eingriffen,</span> ist keine <span style="letter-spacing:-.4pt">PAP</span> <span style="letter-spacing:
-.1pt">nötig.</span> Bei <span style="letter-spacing:-.05pt">stark</span> kontaminierten (septischen) <span style="letter-spacing:.05pt">Eingriffen</span> ist eine <span style="letter-spacing:-.1pt">Therapie</span> <span style="letter-spacing:-.05pt">sinnvoll.</span>
 
'''Zeitpunkt:''' 30 bis 60 Minuten vor Hautschnitt soll die Dosis appliziert sein <span style="letter-spacing:
-.25pt">bzw.</span> Anlage <span style="letter-spacing:-.1pt">der</span> <span style="letter-spacing:-.1pt">Blutsperre.</span>
 
Ausnahmen: Medikamente mit längerer Infusionsdauer, siehe Tabelle, Seite 13-14.
 
Eine <span style="letter-spacing:-.05pt">intraoperative</span> <span style="letter-spacing:
-.1pt">Wiederholung</span> <span style="letter-spacing:-.1pt">der</span> Antibiotikagabe ist nach einem größeren <span style="letter-spacing:-.15pt">Blutverlust</span> (mehr <span style="letter-spacing:.05pt">als</span> 1 <span style="letter-spacing:
-.15pt">Liter)</span><span style="letter-spacing:2.95pt"> </span><span style="letter-spacing:-.05pt">oder</span> <span style="letter-spacing:-.05pt">bei</span> <span style="letter-spacing:-.05pt">länger</span> <span style="letter-spacing:
-.05pt">dauernden</span> <span style="letter-spacing:.05pt">Eingriffen</span> (ein- bis <span style="letter-spacing:-.05pt">zweifache</span> <span style="letter-spacing:-.05pt">Halbwertszeit</span> <span style="letter-spacing:
-.1pt">der</span> Substanz) <span style="letter-spacing:.05pt">indiziert</span> <span style="letter-spacing:-.05pt">(siehe</span><span style="letter-spacing:
2.55pt"> </span><span style="letter-spacing:-.1pt">Tabelle, Seite</span> 13-14).
 
Die <span style="letter-spacing:-.05pt">über</span> die <span style="letter-spacing:-.2pt">OP-Dauer</span> fortgesetzte <span style="letter-spacing:-.1pt">Antibiotika-Therapie</span> <span style="letter-spacing:-.05pt">hat</span> <span style="letter-spacing:.1pt">in</span> <span style="letter-spacing:-.1pt">der</span> <span style="letter-spacing:-.1pt">Regel</span> keine <span style="letter-spacing:-.15pt">Vorteile</span> hinsichtlich <span style="letter-spacing:-.1pt">der</span> <span style="letter-spacing:-.1pt">postoperativen</span> <span style="letter-spacing:-.05pt">Wundinfektionsrate,</span> sondern <span style="letter-spacing:-.1pt">Nachteile</span> bezüglich einer Resistenzentwicklung <span style="letter-spacing:-.05pt">mit</span> <span style="letter-spacing:-.1pt">Suppression</span> <span style="letter-spacing:
-.1pt">der</span><span style="letter-spacing:4.95pt"> </span><span style="letter-spacing:-.05pt">endogenen</span> <span style="letter-spacing:
-.05pt">Flora</span> <span style="letter-spacing:.05pt">und</span> <span style="letter-spacing:-.05pt">Selektion</span> <span style="letter-spacing:
-.1pt">pathogener</span> <span style="letter-spacing:-.1pt">Erreger und soll vermieden werden. Eine erst nach Hautnaht verabreichte PAP hat keinen Einfluss auf die Inzidenz der postoperativen Wundinfektion.</span> <span style="mso-spacerun:yes"> </span>
 
'''PAP bei laufender Antibiotikatherapie:'''
 
mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt"
{| class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" style="border-collapse:collapse;border:none;mso-border-alt:solid windowtext .5pt;"
| style="width:361.25pt;" width="482" valign="top" |Antibiotikatherapie für PAP geeignet
| style="width:12.0cm;" width="454" valign="top" |Antibiotikatherapie nicht für PAP  geeignet
|- style="mso-yfti-irow:1;mso-yfti-lastrow:yes"
| style="width:361.25pt;" width="482" valign="top" |<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">         </span></span>zusätzliche Dosis  60 min. vor Hautschnitt
| style="width:12.0cm;" width="454" valign="top" |<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">         </span></span>zusätzliche PAP  wie für OP empfohlen
|}
'''Antiseptische Waschung vor OP''' (FG Beschluß Orthopädie und Unfallchirurgie Frühjahr 2016):
 
''„Die FG O und U beschließt bei allen Patienten, denen ein Kunstgelenk an der unteren Extremität implantiert wird, antiseptische präoperative Waschungen und die antiseptische Behandlung des Nasenvorhofes durchzuführen“''
 
'''Kolonisierende Mikroorganismen in Abhängigkeit der Lokalisation'''
 
mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt"
{| class="wikitable filterable MsoTableGrid" border="1" cellspacing="0" cellpadding="0" style="border-collapse:collapse;border:none;mso-border-alt:solid windowtext .5pt;"
|+
| style="width:141.5pt;" width="189" valign="top" |'''Körperstelle'''
| style="width:595.1pt;" width="793" valign="top" |'''Mikroorganismen'''
|- style="mso-yfti-irow:1"
| style="width:141.5pt;" width="189" valign="top" |Nase
| style="width:595.1pt;" width="793" valign="top" |''<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-bidi-font-family:Arial-ItalicMT;
  mso-ansi-language:EN-US;mso-fareast-language:DE">Staphylococcus aureus,  Streptococcus pneumoniae, Neisseria meningitidis</span>''
|- style="mso-yfti-irow:2"
| style="width:141.5pt;" width="189" valign="top" |Oberer Respirationstrakt
| style="width:595.1pt;" width="793" valign="top" |''Streptococcus pneumoniae, Haemophilus  influenzae''
|- style="mso-yfti-irow:3"
| style="width:141.5pt;" width="189" valign="top" |Mund/Oropharynx
| style="width:595.1pt;" width="793" valign="top" |''<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-bidi-font-family:Arial-ItalicMT;
  mso-ansi-language:EN-US;mso-fareast-language:DE">Streptococcus</span>'' <span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-bidi-font-family:
  ArialMT;mso-ansi-language:EN-US;mso-fareast-language:DE">sp.</span>''<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-bidi-font-family:
  Arial-ItalicMT;mso-ansi-language:EN-US;mso-fareast-language:DE">, Bacteroides  </span>''<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-bidi-font-family:ArialMT;mso-ansi-language:EN-US;mso-fareast-language:
  DE">sp. </span>''<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-bidi-font-family:Arial-ItalicMT;mso-ansi-language:EN-US;mso-fareast-language:
  DE">(</span>''<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-bidi-font-family:ArialMT;mso-ansi-language:EN-US;mso-fareast-language:
  DE">ausser </span>''<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-bidi-font-family:Arial-ItalicMT;mso-ansi-language:EN-US;mso-fareast-language:
  DE">B. fragilis), Fusobacterium</span>'' <span style="font-size:10.0pt;
  font-family:&quot;Verdana&quot;,sans-serif;mso-bidi-font-family:ArialMT;mso-ansi-language:
  EN-US;mso-fareast-language:DE">spp.</span>''<span style="font-size:10.0pt;
  font-family:&quot;Verdana&quot;,sans-serif;mso-bidi-font-family:Arial-ItalicMT;
  mso-ansi-language:EN-US;mso-fareast-language:DE">, Peptostreptococcus </span>''<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-bidi-font-family:
  ArialMT;mso-ansi-language:EN-US;mso-fareast-language:DE">spp.</span>''<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-bidi-font-family:
  Arial-ItalicMT;mso-ansi-language:EN-US;mso-fareast-language:DE">, Actinomyces  </span>''<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-bidi-font-family:ArialMT;mso-ansi-language:EN-US;mso-fareast-language:
  DE">spp.</span>
|- style="mso-yfti-irow:4"
| style="width:141.5pt;" width="189" valign="top" |Gastroduodenal
| style="width:595.1pt;" width="793" valign="top" |''Escherichia coli, Proteus'' sp.'', Klebsiella'' spp.'', Enterococcus'' spp.
|- style="mso-yfti-irow:5"
| style="width:141.5pt;" width="189" valign="top" |Kolorektal
| style="width:595.1pt;" width="793" valign="top" |''Escherichia coli, Klebsiella'' sp.'', Enterobacter'' spp.'', Bacteroides fragilis,  Peptostreptococcus'' spp.'', Enterococcus'' spp.
|- style="mso-yfti-irow:6"
| style="width:141.5pt;" width="189" valign="top" |Gallenwege
| style="width:595.1pt;" width="793" valign="top" |''Escherichia coli, Klebsiella'' sp.'', Proteus'' spp.'', Enterococcus'' spp.'', Clostridium'' spp.
|- style="mso-yfti-irow:7"
| style="width:141.5pt;" width="189" valign="top" |Harnwege
| style="width:595.1pt;" width="793" valign="top" |''Escherichia coli, Klebsiella'' spp.'', Proteus'' spp.'', Enterobacter'' spp.'', Enterococcus'' spp.
|- style="mso-yfti-irow:8;mso-yfti-lastrow:yes"
| style="width:141.5pt;" width="189" valign="top" |Haut
| style="width:595.1pt;" width="793" valign="top" |''<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-bidi-font-family:Arial-ItalicMT;
  mso-ansi-language:EN-US;mso-fareast-language:DE">Staphylococcus aureus,  Staphylococcus epidermidis, Propionibacterium acnes, Corynebacterium</span>'' <span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-bidi-font-family:
  ArialMT;mso-ansi-language:EN-US;mso-fareast-language:DE">spp.</span>
|}
{| class="wikitable filterable MsoTableGrid" style="width:736.85pt;" border="1" cellspacing="0" cellpadding="0" width="982"
|+
| style="width:276.2pt;" width="368" valign="top" |Eingriffe  nach Infektionsrisiko
| style="width:382.7pt;" width="510" valign="top" |Operationskategorie
| style="width:77.95pt;" width="104" valign="top" |Risiko in %
|- style="mso-yfti-irow:1"
| style="width:276.2pt;" width="368" valign="top" |Sauber (aseptisch), Klasse<span style="mso-spacerun:yes">  </span>I
| style="width:382.7pt;" width="510" valign="top" |aseptische Operationen ohne Eröffnung des Gastro-, Intestinal- oder Respirationstraktes
| style="width:77.95pt;" width="104" valign="top" |1-2 %
|- style="mso-yfti-irow:2"
| style="width:276.2pt;" width="368" valign="top" |Sauber-kontaminiert<span style="letter-spacing:-1.1pt"> </span>(bedingt aseptisch),<span style="letter-spacing:-1.25pt"> </span>Klasse<span style="letter-spacing:
  -1.25pt"> </span>II
| style="width:382.7pt;" width="510" valign="top" |saubere Operationen mit<span style="letter-spacing:1.0pt"> </span><span style="letter-spacing:-.15pt">Er</span><span style="letter-spacing:-.1pt">öffnun</span><span style="letter-spacing:-.15pt">g</span><span style="letter-spacing:1.05pt"> </span><span style="letter-spacing:-.05pt">de</span><span style="letter-spacing:-.1pt">s</span><span style="letter-spacing:1.05pt"> </span><span style="letter-spacing:-.1pt">Ga</span><span style="letter-spacing:-.05pt">stro-, Int</span><span style="letter-spacing:
  -.1pt">e</span><span style="letter-spacing:-.05pt">stinal-,</span><span style="letter-spacing:1.05pt"> </span><span style="letter-spacing:-.1pt">Ur</span><span style="letter-spacing:-.05pt">o</span><span style="letter-spacing:-.1pt">ge</span><span style="letter-spacing:-.05pt">nital-</span><span style="letter-spacing:1.05pt">  </span><span style="letter-spacing:-.05pt">oder</span><span style="letter-spacing:
  2.95pt;mso-font-width:107%"> </span><span style="letter-spacing:-.15pt">Re</span><span style="letter-spacing:-.1pt">spirationstrakt</span><span style="letter-spacing:
  -.15pt">es</span><span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.05pt">ohne</span><span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.1pt">A</span><span style="letter-spacing:-.05pt">ustritt</span><span style="letter-spacing:.25pt"> </span><span style="letter-spacing:-.05pt">von</span><span style="letter-spacing:.45pt"> </span><span style="letter-spacing:-.05pt">Inhalt,</span><span style="letter-spacing:.45pt"> </span><span style="letter-spacing:-.15pt">Ope</span><span style="letter-spacing:-.1pt">rationen</span><span style="letter-spacing:.45pt">  </span>an<span style="letter-spacing:.45pt"> </span>
 
Mucosa und/ oder intertriginösen Arealen
| style="width:77.95pt;" width="104" valign="top" |2-10 %
|- style="mso-yfti-irow:3"
| style="width:276.2pt;" width="368" valign="top" |Kontaminiert<span style="letter-spacing:-1.1pt"> </span>Klasse<span style="letter-spacing:-1.25pt"> </span>III
| style="width:382.7pt;" width="510" valign="top" |Operationen bei<span style="letter-spacing:-.85pt"> </span><span style="letter-spacing:
  -.1pt">ak</span><span style="letter-spacing:-.05pt">ut</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">r</span><span style="letter-spacing:-.85pt"> </span><span style="letter-spacing:-.1pt">E</span><span style="letter-spacing:-.05pt">ntzündun</span><span style="letter-spacing:
  -.1pt">g</span><span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.05pt">und/</span><span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.1pt">ode</span><span style="letter-spacing:-.05pt">r</span><span style="letter-spacing:-.9pt"> </span><span style="letter-spacing:-.1pt">E</span><span style="letter-spacing:-.05pt">ntleerun</span><span style="letter-spacing:
  -.1pt">g</span><span style="letter-spacing:-.85pt"> </span><span style="letter-spacing:-.1pt">vo</span><span style="letter-spacing:-.05pt">n</span><span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.1pt">Ho</span><span style="letter-spacing:-.05pt">hlor</span><span style="letter-spacing:-.1pt">g</span><span style="letter-spacing:-.05pt">aninhalt – Durchbrechung der Asepsis bei der  Versorgung frischer traumatischer Wunden</span>
| style="width:77.95pt;" width="104" valign="top" |3-15 %
|- style="mso-yfti-irow:4;mso-yfti-lastrow:yes"
| style="width:276.2pt;" width="368" valign="top" |Stark<span style="letter-spacing:.6pt"> </span>kontaminiert<span style="letter-spacing:
  .65pt"> </span>(septisch), Klasse IV
| style="width:382.7pt;" width="510" valign="top" |Operationen bei<span style="letter-spacing:.55pt"> </span><span style="letter-spacing:-.15pt">E</span><span style="letter-spacing:-.1pt">it</span><span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-.1pt">r</span><span style="letter-spacing:-.15pt">ans</span><span style="letter-spacing:-.1pt">ammlung,</span><span style="letter-spacing:.55pt"> </span><span style="letter-spacing:-.05pt">n</span><span style="letter-spacing:-.1pt">ac</span><span style="letter-spacing:-.05pt">h</span><span style="letter-spacing:.55pt"> </span><span style="letter-spacing:-.15pt">Pe</span><span style="letter-spacing:-.1pt">rforation</span><span style="letter-spacing:
  .5pt"> </span><span style="letter-spacing:-.05pt">von</span><span style="letter-spacing:.5pt"> </span><span style="letter-spacing:-.15pt">Ho</span><span style="letter-spacing:-.1pt">hlor</span><span style="letter-spacing:-.15pt">g</span><span style="letter-spacing:-.1pt">anen</span><span style="letter-spacing:.55pt"> </span><span style="letter-spacing:-.05pt">und</span><span style="letter-spacing:.55pt"> </span><span style="letter-spacing:-.05pt">allen</span> <span style="letter-spacing:-.1pt">Ve</span><span style="letter-spacing:-.05pt">rletzun</span><span style="letter-spacing:-.1pt">ge</span><span style="letter-spacing:-.05pt">n,</span><span style="letter-spacing:.2pt"> </span><span style="letter-spacing:-.1pt">W</span><span style="letter-spacing:-.05pt">unden,</span><span style="letter-spacing:.2pt"> </span>die<span style="letter-spacing:.25pt"> </span><span style="letter-spacing:-.05pt">län</span><span style="letter-spacing:-.1pt">ge</span><span style="letter-spacing:-.05pt">r</span><span style="letter-spacing:.15pt"> </span>als<span style="letter-spacing:.25pt"> </span>4h<span style="letter-spacing:.2pt"> </span><span style="letter-spacing:-.05pt">best</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">hen</span>
| style="width:77.95pt;" width="104" valign="top" |Bis 40%
|}
 
'''Risikofaktoren für postoperative Wundinfektionen'''
{| class="wikitable filterable MsoTableGrid" style="width:736.85pt;" border="1" cellspacing="0" cellpadding="0" width="982"
|+
| style="width:91.25pt;" width="122" valign="top" |Patienteneigene
| style="width:645.6pt;" width="861" valign="top" |Alter (Zunahme/Dezenium); Diabetes, Immuninkompetenz (z.B. Karzinompatienten), Reduzierter AZ,<span style="letter-spacing:.25pt"> </span><span style="letter-spacing:
  -.1pt">Übe</span><span style="letter-spacing:-.05pt">r</span><span style="letter-spacing:-.1pt">ge</span><span style="letter-spacing:-.05pt">wicht,</span><span style="letter-spacing:-1.3pt"> </span><span style="letter-spacing:-.1pt">M</span><span style="letter-spacing:-.05pt">an</span><span style="letter-spacing:-.1pt">ge</span><span style="letter-spacing:-.05pt">lernährung,</span><span style="letter-spacing:
  -1.3pt"> </span><span style="letter-spacing:-.15pt">ASA</span><span style="letter-spacing:-.1pt">-</span><span style="letter-spacing:-.15pt">Sco</span><span style="letter-spacing:-.1pt">r</span><span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-1.3pt"> </span>> 2,<span style="letter-spacing:
  -1.25pt"> </span><span style="letter-spacing:-.2pt">MSSA/MR</span><span style="letter-spacing:-.25pt">S</span><span style="letter-spacing:-.2pt">A</span><span style="letter-spacing:-.1pt">-</span><span style="letter-spacing:-.25pt">T</span><span style="letter-spacing:-.15pt">r</span><span style="letter-spacing:-.2pt">äge</span><span style="letter-spacing:-.15pt">r,</span><span style="letter-spacing:-1.3pt"> </span><span style="letter-spacing:-.1pt">F</span><span style="letter-spacing:-.05pt">ieber</span><span style="letter-spacing:-1.3pt"> </span>1<span style="letter-spacing:-1.3pt"> </span><span style="letter-spacing:-.1pt">Woc</span><span style="letter-spacing:-.05pt">he</span><span style="letter-spacing:-1.25pt"> </span><span style="letter-spacing:-.15pt">pr</span><span style="letter-spacing:-.2pt">ä-</span><span style="letter-spacing:-.5pt">O</span><span style="letter-spacing:-.45pt">P</span><span style="letter-spacing:-.3pt">,</span><span style="letter-spacing:-1.3pt"> </span><span style="letter-spacing:-.05pt">weibliche</span><span style="letter-spacing:-.1pt">s</span><span style="letter-spacing:-1.3pt"> </span><span style="letter-spacing:-.1pt">Gesc</span><span style="letter-spacing:-.05pt">hle</span><span style="letter-spacing:-.1pt">c</span><span style="letter-spacing:-.05pt">ht  bei</span><span style="letter-spacing:.25pt"> </span><span style="letter-spacing:
  -.15pt">E</span><span style="letter-spacing:-.1pt">in</span><span style="letter-spacing:-.15pt">g</span><span style="letter-spacing:-.1pt">riff</span><span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-.1pt">n</span><span style="letter-spacing:.3pt"> </span>am<span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.1pt">K</span><span style="letter-spacing:-.05pt">olon</span><span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.05pt">und</span><span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.05pt">in</span><span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.05pt">der</span><span style="letter-spacing:.25pt"> </span><span style="letter-spacing:-.15pt">K</span><span style="letter-spacing:-.1pt">ardiochirurgie,</span><span style="letter-spacing:
  .3pt"> </span><span style="letter-spacing:-.05pt">männliche</span><span style="letter-spacing:-.1pt">s</span><span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.1pt">Gesc</span><span style="letter-spacing:-.05pt">hle</span><span style="letter-spacing:-.1pt">c</span><span style="letter-spacing:-.05pt">ht</span><span style="letter-spacing:.25pt"> </span><span style="letter-spacing:-.05pt">n</span><span style="letter-spacing:-.1pt">ac</span><span style="letter-spacing:-.05pt">h</span><span style="letter-spacing:.25pt"> </span><span style="letter-spacing:-.25pt">T</span><span style="letter-spacing:-.15pt">raum</span><span style="letter-spacing:-.2pt">a</span><span style="letter-spacing:-.15pt">,</span><span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.1pt">Gefäßc</span><span style="letter-spacing:-.05pt">hirurgie</span><span style="letter-spacing:.25pt"> </span><span style="letter-spacing:-.05pt">und  Kni</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:
  -.15pt">ge</span><span style="letter-spacing:-.1pt">lenk</span><span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-.1pt">r</span><span style="letter-spacing:-.15pt">s</span><span style="letter-spacing:-.1pt">atz,</span><span style="letter-spacing:.45pt"> </span><span style="letter-spacing:-.1pt">Dialys</span><span style="letter-spacing:-.05pt">epatient</span><span style="letter-spacing:
  -.1pt">e</span><span style="letter-spacing:-.05pt">n,</span><span style="letter-spacing:.5pt"> </span><span style="letter-spacing:-.1pt">Hep</span><span style="letter-spacing:-.05pt">atitis,</span><span style="letter-spacing:.4pt">  </span><span style="letter-spacing:-.15pt">S</span><span style="letter-spacing:
  -.1pt">tom</span><span style="letter-spacing:-.15pt">a</span><span style="letter-spacing:-.1pt">,</span><span style="letter-spacing:.5pt"> </span><span style="letter-spacing:-.1pt">Dr</span><span style="letter-spacing:-.05pt">o</span><span style="letter-spacing:-.1pt">ge</span><span style="letter-spacing:-.05pt">nabusus,</span><span style="letter-spacing:.45pt"> </span><span style="letter-spacing:-.05pt">Inf</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">ktionen</span><span style="letter-spacing:.5pt"> </span><span style="letter-spacing:-.05pt">ander</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">r</span><span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.15pt">L</span><span style="letter-spacing:-.1pt">okalisationen, AVK</span><span style="letter-spacing:
  -.05pt">,</span><span style="letter-spacing:-.55pt"> </span><span style="letter-spacing:-.05pt">peripher</span><span style="letter-spacing:
  -.1pt">e</span> <span style="letter-spacing:-.1pt">Öde</span><span style="letter-spacing:-.05pt">me,</span> <span style="letter-spacing:-.15pt">Ly</span><span style="letter-spacing:-.1pt">mphangitis,</span><span style="letter-spacing:
  -.5pt"> </span><span style="letter-spacing:-.1pt">Neu</span><span style="letter-spacing:-.05pt">ropathie,</span><span style="letter-spacing:
  -.5pt"> </span><span style="letter-spacing:-.1pt">Rauc</span><span style="letter-spacing:-.05pt">hen,</span> <span style="letter-spacing:-.15pt">L</span><span style="letter-spacing:-.1pt">ink</span><span style="letter-spacing:-.15pt">s</span><span style="letter-spacing:-.1pt">he</span><span style="letter-spacing:-.15pt">rzve</span><span style="letter-spacing:-.1pt">r</span><span style="letter-spacing:-.15pt">sage</span><span style="letter-spacing:-.1pt">n</span> <span style="letter-spacing:-.05pt">n</span><span style="letter-spacing:-.1pt">ac</span><span style="letter-spacing:-.05pt">h</span> <span style="letter-spacing:-.1pt">koronar</span><span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-.1pt">m</span> <span style="letter-spacing:-.15pt">By</span><span style="letter-spacing:-.1pt">p</span><span style="letter-spacing:-.15pt">ass,  b</span><span style="letter-spacing:-.05pt">akt</span><span style="letter-spacing:
  -.1pt">e</span><span style="letter-spacing:-.05pt">rielle</span><span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.15pt">T</span><span style="letter-spacing:-.1pt">ranslokation</span><span style="letter-spacing:
  .35pt"> </span>bei<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.15pt">L</span><span style="letter-spacing:-.1pt">aparotomie,</span><span style="letter-spacing:.35pt"> </span><span style="letter-spacing:-.1pt">Rheu</span><span style="letter-spacing:-.05pt">matoide</span><span style="letter-spacing:.3pt">  </span><span style="letter-spacing:-.1pt">Ar</span><span style="letter-spacing:
  -.05pt">thrit</span><span style="letter-spacing:-.1pt">is</span><span style="letter-spacing:.4pt"> </span>bei<span style="letter-spacing:.35pt"> </span><span style="letter-spacing:-.1pt">K</span><span style="letter-spacing:-.05pt">nie</span><span style="letter-spacing:-.1pt">ge</span><span style="letter-spacing:-.05pt">lenk</span><span style="letter-spacing:-.1pt">se</span><span style="letter-spacing:-.05pt">r</span><span style="letter-spacing:-.1pt">s</span><span style="letter-spacing:-.05pt">atz,</span><span style="letter-spacing:.35pt"> </span><span style="letter-spacing:-.1pt">Z</span><span style="letter-spacing:-.05pt">irr</span><span style="letter-spacing:-.1pt">hos</span><span style="letter-spacing:-.05pt">e; Risikofaktoren in der Dermatochirurgie nach  Lokalisation: Bein unterhalb Knie, Leiste, Keilexzision Lippe oder Ohr,</span><span style="letter-spacing:1.4pt;mso-font-width:95%"> </span><span style="letter-spacing:-.1pt">Ve</span><span style="letter-spacing:-.05pt">rletzun</span><span style="letter-spacing:-.1pt">g</span> <span style="letter-spacing:-.05pt">der</span> <span style="letter-spacing:-.1pt">Sc</span><span style="letter-spacing:-.05pt">hleimhautbarrier</span><span style="letter-spacing:
  -.1pt">e</span><span style="letter-spacing:-.05pt">,</span> <span style="letter-spacing:-.1pt">L</span><span style="letter-spacing:-.05pt">appenpl</span><span style="letter-spacing:-.1pt">a</span><span style="letter-spacing:-.05pt">stik</span> <span style="letter-spacing:-.05pt">der</span>  <span style="letter-spacing:-.1pt">Nase</span><span style="letter-spacing:
  -.05pt">,</span> <span style="letter-spacing:-.1pt">W</span><span style="letter-spacing:-.05pt">undv</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">r</span><span style="letter-spacing:-.1pt">sc</span><span style="letter-spacing:-.05pt">hlüss</span><span style="letter-spacing:-.1pt">e</span> bei <span style="letter-spacing:-.1pt">2-</span><span style="letter-spacing:-.15pt">z</span><span style="letter-spacing:-.1pt">eiti</span><span style="letter-spacing:-.15pt">ge</span><span style="letter-spacing:-.1pt">m Vor</span><span style="letter-spacing:-.15pt">ge</span><span style="letter-spacing:-.1pt">hen,</span><span style="letter-spacing:.8pt"> </span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">ntzündliche</span><span style="letter-spacing:
  .85pt"> </span><span style="letter-spacing:-.15pt">H</span><span style="letter-spacing:-.1pt">aut</span><span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-.1pt">rkrankun</span><span style="letter-spacing:-.15pt">ge</span><span style="letter-spacing:-.1pt">n</span>
|- style="mso-yfti-irow:1"
| colspan="2" style="width:736.85pt;" width="982" valign="top" |''Chirurgische Faktoren''
|- style="mso-yfti-irow:2"
| style="width:91.25pt;" width="122" valign="top" |präoperative
| style="width:645.6pt;" width="861" valign="top" |Notfalloperation, längerer präoperativer Krankenhausaufenthalt, falsche Wahl des AB<span style="letter-spacing:.55pt"> </span><span style="letter-spacing:-.05pt">und</span><span style="letter-spacing:.55pt"> </span><span style="letter-spacing:-.1pt">f</span><span style="letter-spacing:-.15pt">alsc</span><span style="letter-spacing:-.1pt">her</span><span style="letter-spacing:.35pt"> </span><span style="letter-spacing:-.1pt">Z</span><span style="letter-spacing:-.05pt">eitpunkt</span><span style="letter-spacing:5.05pt;mso-font-width:110%"> </span><span style="letter-spacing:-.05pt">der</span><span style="letter-spacing:.15pt"> </span><span style="letter-spacing:-.1pt">G</span><span style="letter-spacing:-.05pt">abe,</span><span style="letter-spacing:.2pt"> </span><span style="letter-spacing:-.15pt">V</span><span style="letter-spacing:-.1pt">orbe</span><span style="letter-spacing:-.15pt">st</span><span style="letter-spacing:-.1pt">rahlung,</span><span style="letter-spacing:.25pt">  </span><span style="letter-spacing:-.1pt">Hoc</span><span style="letter-spacing:
  -.05pt">hrisikooperation,</span><span style="letter-spacing:.2pt"> </span><span style="letter-spacing:-.15pt">Re</span><span style="letter-spacing:-.1pt">zidi</span><span style="letter-spacing:-.15pt">v</span><span style="letter-spacing:-.1pt">ein</span><span style="letter-spacing:-.15pt">g</span><span style="letter-spacing:-.1pt">riff</span><span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-.1pt">,</span><span style="letter-spacing:.2pt"> </span><span style="letter-spacing:-.1pt">S</span><span style="letter-spacing:-.05pt">teine</span><span style="letter-spacing:.25pt">  </span><span style="letter-spacing:-.05pt">im</span><span style="letter-spacing:
  .25pt"> </span><span style="letter-spacing:-.1pt">G</span><span style="letter-spacing:-.05pt">allen</span><span style="letter-spacing:-.1pt">g</span><span style="letter-spacing:-.05pt">an</span><span style="letter-spacing:-.1pt">g</span><span style="letter-spacing:.2pt"> </span><span style="letter-spacing:-.05pt">oder</span>  <span style="letter-spacing:.5pt"><span style="mso-spacerun:yes"> </span></span><span style="letter-spacing:-.15pt">G</span><span style="letter-spacing:-.1pt">allen</span><span style="letter-spacing:-.15pt">g</span><span style="letter-spacing:-.1pt">an</span><span style="letter-spacing:-.15pt">gsve</span><span style="letter-spacing:-.1pt">rsc</span><span style="letter-spacing:-.05pt">hluß,</span><span style="letter-spacing:.35pt">  </span><span style="letter-spacing:-.1pt">Er</span><span style="letter-spacing:
  -.05pt">höht</span><span style="letter-spacing:-.1pt">es</span><span style="letter-spacing:.35pt"> </span><span style="letter-spacing:-.45pt">CR</span><span style="letter-spacing:-.4pt">P</span><span style="letter-spacing:-.3pt">,</span><span style="letter-spacing:.35pt"> </span><span style="letter-spacing:-.15pt">F</span><span style="letter-spacing:-.1pt">r</span><span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-.1pt">mdkörperimplantationen,</span><span style="letter-spacing:.35pt"> </span><span style="letter-spacing:-.1pt">Rasu</span><span style="letter-spacing:-.05pt">r</span><span style="letter-spacing:.25pt"> </span><span style="letter-spacing:-.05pt">nicht</span><span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.05pt">unmitt</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">lbar</span><span style="letter-spacing:.2pt"> </span><span style="letter-spacing:-.05pt">vor</span><span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.5pt">O</span><span style="letter-spacing:-.45pt">P</span><span style="letter-spacing:-.3pt">,</span><span style="letter-spacing:.35pt"> </span><span style="letter-spacing:-.1pt">pr</span><span style="letter-spacing:-.15pt">äope</span><span style="letter-spacing:-.1pt">rati</span><span style="letter-spacing:-.15pt">ve</span><span style="letter-spacing:-.1pt">r</span><span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.1pt">Ur</span><span style="letter-spacing:-.05pt">inkathe</span><span style="letter-spacing:-.2pt">t</span><span style="letter-spacing:-.25pt">e</span><span style="letter-spacing:-.2pt">r,</span> <span style="letter-spacing:-.15pt">V</span><span style="letter-spacing:-.1pt">or</span><span style="letter-spacing:-.15pt">ausgeg</span><span style="letter-spacing:-.1pt">an</span><span style="letter-spacing:-.15pt">ge</span><span style="letter-spacing:-.1pt">ne</span> <span style="letter-spacing:-.1pt">(neur</span><span style="letter-spacing:-.15pt">oc</span><span style="letter-spacing:-.1pt">hirur</span><span style="letter-spacing:-.15pt">gisc</span><span style="letter-spacing:-.1pt">he)</span> <span style="letter-spacing:-.15pt">E</span><span style="letter-spacing:-.1pt">in</span><span style="letter-spacing:-.15pt">g</span><span style="letter-spacing:-.1pt">riff</span><span style="letter-spacing:-.15pt">e</span>
|- style="mso-yfti-irow:3"
| style="width:91.25pt;" width="122" valign="top" |intraoperativ
| style="width:645.6pt;" width="861" valign="top" |Erfahrung des Chirurgen, OP-Dauer >2h,<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.05pt">infiziert</span><span style="letter-spacing:
  -.1pt">e</span><span style="letter-spacing:-.05pt">r</span><span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.1pt">OP-Be</span><span style="letter-spacing:-.05pt">r</span><span style="letter-spacing:-.1pt">eic</span><span style="letter-spacing:-.05pt">h,</span><span style="letter-spacing:.35pt"> </span><span style="letter-spacing:-.1pt">kontaminiert</span><span style="letter-spacing:
  -.15pt">e</span><span style="letter-spacing:-.1pt">r</span><span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.1pt">OP-Be</span><span style="letter-spacing:-.05pt">r</span><span style="letter-spacing:-.1pt">eic</span><span style="letter-spacing:-.05pt">h,</span><span style="letter-spacing:.35pt"> </span><span style="letter-spacing:-.05pt">Bluttransfusion,</span><span style="letter-spacing:
  3.85pt;mso-font-width:111%"> </span><span style="letter-spacing:-.1pt">Albuminzufuhr,</span><span style="letter-spacing:.95pt"> </span><span style="letter-spacing:-.05pt">lan</span><span style="letter-spacing:-.1pt">ge</span><span style="letter-spacing:.95pt"> </span><span style="letter-spacing:-.15pt">Anäst</span><span style="letter-spacing:-.1pt">hesied</span><span style="letter-spacing:-.15pt">aue</span><span style="letter-spacing:-.1pt">r,</span><span style="letter-spacing:1.0pt"> </span><span style="letter-spacing:-.1pt">Di</span><span style="letter-spacing:-.05pt">athermie,</span><span style="letter-spacing:
  .9pt"> </span><span style="letter-spacing:-.1pt">S</span><span style="letter-spacing:-.05pt">auerstoffabfall,</span><span style="letter-spacing:
  1.0pt"> </span><span style="letter-spacing:-.1pt">Un</span><span style="letter-spacing:-.05pt">t</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">rkühlung,</span><span style="letter-spacing:
  1.0pt"> </span><span style="letter-spacing:-.15pt">W</span><span style="letter-spacing:-.1pt">undstapler,</span><span style="letter-spacing:
  1.0pt"> </span><span style="letter-spacing:-.1pt">un</span><span style="letter-spacing:-.15pt">v</span><span style="letter-spacing:-.1pt">orher</span><span style="letter-spacing:-.15pt">se</span><span style="letter-spacing:-.1pt">hbar</span><span style="letter-spacing:-.15pt">e</span> <span style="letter-spacing:-.1pt">K</span><span style="letter-spacing:-.05pt">omplikationen,</span> <span style="letter-spacing:
  -.15pt">OP-Tec</span><span style="letter-spacing:-.1pt">hnik,</span> <span style="letter-spacing:-.15pt">Ve</span><span style="letter-spacing:-.1pt">rfahr</span><span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-.1pt">nsw</span><span style="letter-spacing:-.15pt">echse</span><span style="letter-spacing:-.1pt">l</span>  <span style="letter-spacing:-.15pt">L</span><span style="letter-spacing:-.1pt">apar</span><span style="letter-spacing:-.15pt">os</span><span style="letter-spacing:-.1pt">kopie/</span><span style="letter-spacing:-.15pt">L</span><span style="letter-spacing:-.1pt">aparotomie,</span> <span style="letter-spacing:-.15pt">E</span><span style="letter-spacing:-.1pt">nt</span><span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-.1pt">rokokk</span><span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-.1pt">n,</span> <span style="letter-spacing:-.15pt">E</span><span style="letter-spacing:-.1pt">nt</span><span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-.1pt">ro</span><span style="letter-spacing:-.05pt">bakt</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">rien,</span><span style="letter-spacing:.45pt"> </span><span style="letter-spacing:-.15pt">Bac</span><span style="letter-spacing:-.1pt">t</span><span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-.1pt">roide</span><span style="letter-spacing:-.15pt">s</span><span style="letter-spacing:.5pt"> </span><span style="letter-spacing:-.1pt">fr</span><span style="letter-spacing:-.15pt">a</span><span style="letter-spacing:-.1pt">gilis</span><span style="letter-spacing:.5pt"> </span><span style="letter-spacing:-.05pt">in</span><span style="letter-spacing:.5pt"> </span><span style="letter-spacing:-.05pt">der</span><span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.1pt">W</span><span style="letter-spacing:-.05pt">unde</span>
|- style="mso-yfti-irow:4;mso-yfti-lastrow:yes"
| style="width:91.25pt;" width="122" valign="top" |postoperativ
| style="width:645.6pt;" width="861" valign="top" |Drainagedauer länger als 3<span style="letter-spacing:-.35pt"> </span><span style="letter-spacing:-.3pt">T</span><span style="letter-spacing:-.25pt">age</span><span style="letter-spacing:-.2pt">,</span> <span style="letter-spacing:-.2pt">r</span><span style="letter-spacing:-.25pt">e</span><span style="letter-spacing:-.2pt">spirat</span><span style="letter-spacing:-.25pt">o</span><span style="letter-spacing:-.2pt">r</span><span style="letter-spacing:-.25pt">isc</span><span style="letter-spacing:-.2pt">he</span><span style="letter-spacing:-.35pt"> </span><span style="letter-spacing:-.15pt">Sepsis,</span>  <span style="letter-spacing:-.2pt">in</span><span style="letter-spacing:
  -.25pt">vasive</span><span style="letter-spacing:-.35pt"> </span><span style="letter-spacing:-.3pt">T</span><span style="letter-spacing:-.25pt">ec</span><span style="letter-spacing:-.2pt">hnik</span><span style="letter-spacing:-.25pt">e</span><span style="letter-spacing:-.2pt">n</span> <span style="letter-spacing:-.25pt">(Ur</span><span style="letter-spacing:-.2pt">inkathet</span><span style="letter-spacing:-.25pt">e</span><span style="letter-spacing:-.2pt">r,</span><span style="letter-spacing:-.35pt"> </span><span style="letter-spacing:-.25pt">Tho</span><span style="letter-spacing:-.2pt">r</span><span style="letter-spacing:-.25pt">a</span><span style="letter-spacing:-.2pt">xdrain</span><span style="letter-spacing:-.25pt">age</span><span style="letter-spacing:-.2pt">, Nasenso</span><span style="letter-spacing:
  -.15pt">nde,</span> <span style="letter-spacing:-.15pt">ZVK),</span>  <span style="letter-spacing:-.2pt">Dialyse</span><span style="letter-spacing:-.15pt">,</span><span style="letter-spacing:-.35pt"> </span><span style="letter-spacing:-.15pt">frühe</span><span style="letter-spacing:-.35pt">  </span><span style="letter-spacing:-.2pt">R</span><span style="letter-spacing:
  -.15pt">e-Operation</span> <span style="letter-spacing:-.15pt">w</span><span style="letter-spacing:-.2pt">ege</span><span style="letter-spacing:-.15pt">n</span><span style="letter-spacing:-.35pt"> </span><span style="letter-spacing:-.15pt">Blutung,</span><span style="letter-spacing:
  -.35pt"> </span><span style="letter-spacing:-.2pt">L</span><span style="letter-spacing:-.15pt">iquorle</span><span style="letter-spacing:-.2pt">c</span><span style="letter-spacing:-.15pt">k</span> <span style="letter-spacing:-.1pt">der</span> <span style="letter-spacing:-.25pt">Z</span><span style="letter-spacing:-.2pt">e</span><span style="letter-spacing:-.15pt">r</span><span style="letter-spacing:-.2pt">e</span><span style="letter-spacing:-.15pt">brospinalflüssi</span><span style="letter-spacing:
  -.2pt">g</span><span style="letter-spacing:-.15pt">keit,</span><span style="letter-spacing:4.3pt;mso-font-width:117%"> </span><span style="letter-spacing:-.2pt">e</span><span style="letter-spacing:-.15pt">xterner</span> <span style="letter-spacing:-.25pt">S</span><span style="letter-spacing:-.15pt">hunt</span>
|}
'''Perioperative''' '''Antibiotika-Prophylaxe'''
 
'''Cave: immer ab 120kg KG bzw. BMI > 35: Cefuroxim/Cefazolin 3g'''
 
solid windowtext .5pt;mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt"
{| class="wikitable filterable MsoTableGrid" border="1" cellspacing="0" cellpadding="0" style="margin-left:5.4pt;border-collapse:collapse;border:none;mso-border-alt:"
|+
| style="width:182.85pt;" width="244" valign="top" |Eingriffe 
| style="width:288.3pt;" width="384" valign="top" |Operationen
| style="width:260.05pt;" width="347" valign="top" |Antibiotika
|- style="mso-yfti-irow:1"
| rowspan="7" style="width:182.85pt;" width="244" valign="top" |'''Chirurgische /  Viszeralchirurgische Eingriffe'''
| style="width:288.3pt;" width="384" valign="top" |Kolorektale Eingriffe (Resektionen, Kolotomien, AP-Anlage/Rückverlegung, Rektumamputation, Bypässe) 
| style="width:260.05pt;" width="347" valign="top" |Cefuroxim 1,5g <span style="letter-spacing:
  -.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span><span style="letter-spacing:-.35pt"> </span>+ <span style="letter-spacing:-.15pt">Me</span><span style="letter-spacing:-.1pt">tr</span><span style="letter-spacing:-.15pt">o</span><span style="letter-spacing:-.1pt">nid</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">ol</span><span style="letter-spacing:-.35pt"> </span>500<span style="letter-spacing:-.05pt">m</span><span style="letter-spacing:-.1pt">g</span><span style="letter-spacing:-.35pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.</span>
 
Cefazolin 2g <span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span> + <span style="letter-spacing:-.15pt">Me</span><span style="letter-spacing:-.1pt">tr</span><span style="letter-spacing:-.15pt">o</span><span style="letter-spacing:-.1pt">nid</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">ol</span> 500<span style="letter-spacing:-.05pt">m</span><span style="letter-spacing:-.1pt">g</span> <span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.</span>
 
''Cave: Resistenzlage für  E.coli beachten, ggf. Ampicillin, Sulbactam (Unacid) 3g i.v. wählen''
|- style="mso-yfti-irow:2"
| style="width:288.3pt;" width="384" valign="top" |Appendektomie
| style="width:260.05pt;" width="347" valign="top" |Cefuroxim 1,5g <span style="letter-spacing:
  -.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span><span style="letter-spacing:-.35pt"> </span>+ <span style="letter-spacing:-.15pt">Me</span><span style="letter-spacing:-.1pt">tr</span><span style="letter-spacing:-.15pt">o</span><span style="letter-spacing:-.1pt">nid</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">ol</span><span style="letter-spacing:-.35pt"> </span>500<span style="letter-spacing:-.05pt">m</span><span style="letter-spacing:-.1pt">g</span><span style="letter-spacing:-.35pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.</span>
 
Cefazolin 2g <span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span> + <span style="letter-spacing:-.15pt">Me</span><span style="letter-spacing:-.1pt">tr</span><span style="letter-spacing:-.15pt">o</span><span style="letter-spacing:-.1pt">nid</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">ol</span> 500<span style="letter-spacing:-.05pt">m</span><span style="letter-spacing:-.1pt">g</span> <span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.</span>
|- style="mso-yfti-irow:3"
| style="width:288.3pt;" width="384" valign="top" |Eingriffe an <span style="letter-spacing:-.1pt">Ösophagus,</span> <span style="letter-spacing:-.1pt">Mage</span><span style="letter-spacing:-.05pt">n,</span> <span style="letter-spacing:-.2pt">P</span><span style="letter-spacing:-.15pt">ankr</span><span style="letter-spacing:-.2pt">eas,</span>  <span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-.1pt">xtrahepa</span><span style="letter-spacing:-.05pt">t</span><span style="letter-spacing:-.1pt">isc</span><span style="letter-spacing:-.05pt">hen</span><span style="letter-spacing:.5pt"> </span><span style="letter-spacing:-.1pt">G</span><span style="letter-spacing:-.05pt">allenw</span><span style="letter-spacing:-.1pt">ege</span><span style="letter-spacing:-.05pt">n</span><span style="letter-spacing:.5pt"> </span><span style="letter-spacing:-.05pt">und</span><span style="letter-spacing:.55pt"> </span><span style="letter-spacing:-.1pt">Dü</span><span style="letter-spacing:-.05pt">nndarm,</span><span style="letter-spacing:.5pt">  </span><span style="letter-spacing:-.1pt">Le</span><span style="letter-spacing:
  -.05pt">berr</span><span style="letter-spacing:-.1pt">ese</span><span style="letter-spacing:-.05pt">ktionen;</span><span style="letter-spacing:
  1.45pt;mso-font-width:113%"> </span><span style="letter-spacing:-.1pt">kon</span><span style="letter-spacing:-.15pt">ve</span><span style="letter-spacing:-.1pt">ntionelle</span><span style="letter-spacing:.7pt"> </span><span style="letter-spacing:-.05pt">(off</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">ne)</span><span style="letter-spacing:.75pt"> </span><span style="letter-spacing:-.1pt">C</span><span style="letter-spacing:-.05pt">hole</span><span style="letter-spacing:-.1pt">zyste</span><span style="letter-spacing:-.05pt">ktomie,</span><span style="letter-spacing:.75pt">  </span><span style="letter-spacing:-.05pt">akut</span><span style="letter-spacing:
  -.1pt">e</span><span style="letter-spacing:1.85pt;mso-font-width:94%"> </span><span style="letter-spacing:-.1pt">C</span><span style="letter-spacing:-.05pt">hole</span><span style="letter-spacing:-.1pt">zyste</span><span style="letter-spacing:-.05pt">ktomie</span>
| style="width:260.05pt;" width="347" valign="top" |Cefuroxim 1,5g <span style="letter-spacing:
  -.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span><span style="letter-spacing:-.35pt"> </span>+ <span style="letter-spacing:-.15pt">Me</span><span style="letter-spacing:-.1pt">tr</span><span style="letter-spacing:-.15pt">o</span><span style="letter-spacing:-.1pt">nid</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">ol</span><span style="letter-spacing:-.35pt"> </span>500<span style="letter-spacing:-.05pt">m</span><span style="letter-spacing:-.1pt">g</span><span style="letter-spacing:-.35pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.</span>
 
Cefazolin 2g <span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span> + <span style="letter-spacing:-.15pt">Me</span><span style="letter-spacing:-.1pt">tr</span><span style="letter-spacing:-.15pt">o</span><span style="letter-spacing:-.1pt">nid</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">ol</span> 500<span style="letter-spacing:-.05pt">m</span><span style="letter-spacing:-.1pt">g</span> <span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.</span>
|- style="mso-yfti-irow:4"
| style="width:288.3pt;" width="384" valign="top" |offene  Herniotomie mit Netzimplantation
| style="width:260.05pt;" width="347" valign="top" |ggf. Cefuroxim 1,5g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:
  -.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.15pt">efaz</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:-.75pt"> </span>2g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:5"
| style="width:288.3pt;" width="384" valign="top" |Laparoskopische Hernienreparation, elektive (laparoskopische Cholecystektomie
| style="width:260.05pt;" width="347" valign="top" |Keine PAP
|- style="mso-yfti-irow:6"
| style="width:288.3pt;" width="384" valign="top" |Schilddrüseneingriffe mit <span style="letter-spacing:-.1pt">S</span><span style="letter-spacing:-.05pt">t</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">rnotomie</span>
| style="width:260.05pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:
  -.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.15pt">efaz</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:-.8pt"> </span>2g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:7"
| style="width:288.3pt;" width="384" valign="top" |Proktologische  Eingriffe (z.B. Hämorrhoiden, Fisteln, Abszesse)
| style="width:260.05pt;" width="347" valign="top" |Im Regelfall keine PAP  erforderlich
|- style="height:21.95ptpx;"
| rowspan="4" style="width:182.85pt;" width="244" valign="top" |'''Endoskopische Eingriffe'''
| style="width:288.3pt;" width="384" valign="top" |ERCP<span style="letter-spacing:-.85pt"> </span>mit<span style="letter-spacing:-.85pt"> </span><span style="letter-spacing:-.05pt">Int</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">rv</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">ntionen</span><span style="letter-spacing:-.85pt"> </span>bei<span style="letter-spacing:-.85pt">  </span><span style="letter-spacing:-.1pt">z.B</span><span style="letter-spacing:
  -.05pt">.</span><span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.1pt">C</span><span style="letter-spacing:-.05pt">holest</span><span style="letter-spacing:-.1pt">as</span><span style="letter-spacing:-.05pt">e;</span><span style="letter-spacing:1.2pt;mso-font-width:103%"> </span><span style="letter-spacing:-.1pt">E</span><span style="letter-spacing:-.05pt">ndoskopis</span><span style="letter-spacing:-.1pt">c</span><span style="letter-spacing:-.05pt">he</span><span style="letter-spacing:-.9pt"> </span><span style="letter-spacing:-.1pt">P</span><span style="letter-spacing:-.05pt">unktion</span><span style="letter-spacing:-.9pt">  </span><span style="letter-spacing:-.1pt">zystisc</span><span style="letter-spacing:-.05pt">her</span><span style="letter-spacing:-.9pt"> </span><span style="letter-spacing:-.1pt">Lä</span><span style="letter-spacing:-.05pt">sionen</span>
| style="width:260.05pt;" width="347" valign="top" |<span style="color: black">C</span><span style="color: black">eftriaxon</span><span style="color: black"> </span><span style="color: black">2g<span style="letter-spacing:-.9pt"> </span><span style="letter-spacing:
  -.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:-.9pt"> </span><span style="letter-spacing:-.05pt">Ampicillin-</span><span style="letter-spacing:
  -.1pt">Sulbac</span><span style="letter-spacing:-.05pt">t</span><span style="letter-spacing:-.1pt">am</span></span><span style="color: black"> </span><span style="color: black">3g<span style="letter-spacing:.75pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.</span></span>
|- style="mso-yfti-irow:9"
| style="width:288.3pt;" width="384" valign="top" |PEG-Anlage
| style="width:260.05pt;" width="347" valign="top" |Cefazolin 2g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">efuroxim</span><span style="letter-spacing:.4pt"> </span>1,5g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:10"
| style="width:288.3pt;" width="384" valign="top" |Ösophagusvarizen ohne Blutung
| style="width:260.05pt;" width="347" valign="top" |Keine PAP
|- style="mso-yfti-irow:11"
| style="width:288.3pt;" width="384" valign="top" |Radiofrequenzablation (RFA)
| style="width:260.05pt;" width="347" valign="top" |Individuelle  Fallentscheidung vor Ort
|- style="mso-yfti-irow:12"
| rowspan="4" style="width:182.85pt;" width="244" valign="top" |'''Kardio-/Gefäßchirurgische'''
 
'''Eingriffe'''
| style="width:288.3pt;" width="384" valign="top" |Aortocoronarer Bypass<sup>1)</sup>, Klappenersatzoperationen<sup><span style="position:relative;top:-2.5pt;mso-text-raise:2.5pt">1)</span></sup> (incl.transfemorale-,apikale Klappenimplantation), Herztransplantationen<sup><span style="position:relative;top:-2.5pt;mso-text-raise:2.5pt">1)</span></sup>
| style="width:260.05pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:
  -.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span> Cefazolin 2g<span style="letter-spacing:-1.2pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
 
''bis<span style="letter-spacing:.25pt"> </span>zu<span style="letter-spacing:.25pt"> </span>24h<span style="mso-font-width:105%"> </span><span style="letter-spacing:-.05pt">möglich</span>,  Evidenz für Gabe über OP hinaus unklar (vgl. WHO Guidelines)''
|- style="mso-yfti-irow:13"
| style="width:288.3pt;" width="384" valign="top" |Arterielle Eingriffe der unteren Extremität und Aorta; Im<span style="letter-spacing:-.05pt">plantationen</span><span style="letter-spacing:.6pt"> </span><span style="letter-spacing:-.05pt">von</span><span style="letter-spacing:.65pt"> </span><span style="letter-spacing:-.1pt">Gefäß</span><span style="letter-spacing:-.05pt">prothe</span><span style="letter-spacing:-.1pt">se</span><span style="letter-spacing:-.05pt">n</span><span style="letter-spacing:.65pt"> </span><span style="letter-spacing:-.05pt">der</span><span style="letter-spacing:.6pt"> </span><span style="letter-spacing:-.15pt">g</span><span style="letter-spacing:-.1pt">r</span><span style="letter-spacing:-.15pt">oße</span><span style="letter-spacing:-.1pt">n</span><span style="letter-spacing:.65pt"> </span><span style="letter-spacing:-.05pt">art</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">riellen</span><span style="letter-spacing:1.75pt;mso-font-width:108%"> </span><span style="letter-spacing:-.1pt">Gefäße (z.B</span><span style="letter-spacing:
  -.05pt">.</span> <span style="letter-spacing:-.1pt">Ao</span><span style="letter-spacing:-.05pt">rt</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">nst</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">nt);</span> <span style="letter-spacing:-.1pt">Shu</span><span style="letter-spacing:-.05pt">ntoperationen</span> <span style="letter-spacing:
  -.1pt">(Re</span><span style="letter-spacing:-.05pt">zidi</span><span style="letter-spacing:-.1pt">v)</span>
| style="width:260.05pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:
  -.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.15pt">efaz</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:-.8pt"> </span>2g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:14"
| style="width:288.3pt;" width="384" valign="top" |Rezidiv Varikosis
| style="width:260.05pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">ef</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:.4pt"> </span>2g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:15;mso-yfti-lastrow:yes"
| style="width:288.3pt;" width="384" valign="top" |Schrittmacher, Port
| style="width:260.05pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">ef</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:.4pt"> </span>2g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|}
'''Cave: immer ab 120kg KG bzw. BMI > 35: Cefuroxim/Cefazolin 3g'''
 
solid windowtext .5pt;mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt"
{| class="wikitable filterable MsoTableGrid" border="1" cellspacing="0" cellpadding="0" style="margin-left:5.4pt;border-collapse:collapse;border:none;mso-border-alt:"
|+
| style="width:182.8pt;" width="244" valign="top" |Eingriffe 
| style="width:288.3pt;" width="384" valign="top" |Operationen
| style="width:260.1pt;" width="347" valign="top" |Antibiotika
|- style="mso-yfti-irow:1"
| style="width:182.8pt;" width="244" valign="top" |'''Thoraxchirurgische Eingriffe'''
| style="width:288.3pt;" width="384" valign="top" |Thorakoskopische Eingriffe, Thorakotomie und lungen- resezierende Eingriffe, Operationen an<span style="letter-spacing:.25pt"> </span><span style="letter-spacing:-.05pt">der</span><span style="letter-spacing:.2pt"> </span><span style="letter-spacing:-.1pt">Br</span><span style="letter-spacing:-.05pt">ustwand</span><span style="letter-spacing:3.45pt;mso-font-width:104%"> </span><span style="letter-spacing:-.1pt">so</span><span style="letter-spacing:-.05pt">wie</span>  <span style="letter-spacing:-.05pt">de</span><span style="letter-spacing:
  -.1pt">s</span> <span style="letter-spacing:-.1pt">M</span><span style="letter-spacing:-.05pt">edi</span><span style="letter-spacing:-.1pt">a</span><span style="letter-spacing:-.05pt">stinu</span><span style="letter-spacing:-.1pt">ms</span>
| style="width:260.1pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:-.75pt"> </span><span style="letter-spacing:
  -.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:-.7pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.15pt">efaz</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:-.75pt"> </span>2g<span style="letter-spacing:-.7pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span> Ampicillin-Sulbactam 3g<span style="letter-spacing:-.35pt"> </span><span style="letter-spacing:
  -.25pt">i.</span><span style="letter-spacing:-.3pt">v</span>
|- style="mso-yfti-irow:2"
| rowspan="10" style="width:182.8pt;" width="244" valign="top" |'''Geburtshilfe und  Gynäkologische Eingriffe'''
| style="width:288.3pt;" width="384" valign="top" |Radikale Eingriffe; abdominelle Hysterektomie (Laparoskopische Eingriffe; LASH; TLH), vaginale Hysterektomie
| style="width:260.1pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.15pt">efaz</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:-.8pt"> </span>2g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
 
(bei drohender oder geplanter Darmeröffnung Metronidazol 0,5 g i.V.  dazu geben)
|- style="mso-yfti-irow:3"
| style="width:288.3pt;" width="384" valign="top" |Inkontinenzchirurgie
| style="width:260.1pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.15pt">efaz</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:-.8pt"> </span>2g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:4"
| style="width:288.3pt;" width="384" valign="top" |Operative Hysteroskopien (Chromopertubation, Sterilitätsoperation)
| style="width:260.1pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.15pt">efaz</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:-.8pt"> </span>2g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:5"
| style="width:288.3pt;" width="384" valign="top" |Diagnostische Hysteroskopien
| style="width:260.1pt;" width="347" valign="top" |Keine PAP
|- style="mso-yfti-irow:6"
| style="width:288.3pt;" width="384" valign="top" |Mammachirurgie
| style="width:260.1pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">ef</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:.4pt"> </span>2g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:7"
| style="width:288.3pt;" width="384" valign="top" |Diagnostische Mammapunktionen: Hochgeschwindig- keitsstanze, <span style="letter-spacing:-.15pt">ste</span><span style="letter-spacing:-.1pt">reotakt</span><span style="letter-spacing:-.15pt">isc</span><span style="letter-spacing:-.1pt">h</span>  <span style="letter-spacing:-.1pt">ge</span><span style="letter-spacing:-.05pt">steuert</span><span style="letter-spacing:-.1pt">e</span> <span style="letter-spacing:-.1pt">V</span><span style="letter-spacing:-.05pt">akuumbiopsie</span>
| style="width:260.1pt;" width="347" valign="top" |Keine PAP
|- style="mso-yfti-irow:8"
| style="width:288.3pt;" width="384" valign="top" |Vaginale Entbindung z.B. bei<span style="letter-spacing:.3pt"> </span><span style="letter-spacing:
  -.1pt">Nac</span><span style="letter-spacing:-.05pt">ht</span><span style="letter-spacing:-.1pt">a</span><span style="letter-spacing:-.05pt">stung,</span><span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.1pt">Nac</span><span style="letter-spacing:-.05pt">hblutun</span><span style="letter-spacing:-.1pt">g</span><span style="letter-spacing:1.55pt;mso-font-width:94%"> </span><span style="letter-spacing:-.05pt">in</span><span style="letter-spacing:.8pt"> </span><span style="letter-spacing:-.05pt">der</span><span style="letter-spacing:.8pt"> </span><span style="letter-spacing:-.05pt">Episiotomie</span>
| style="width:260.1pt;" width="347" valign="top" |siehe HE Geburtshilfe
|- style="mso-yfti-irow:9"
| style="width:288.3pt;" width="384" valign="top" |Kaiserschnittentbindung
| style="width:260.1pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">ef</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:.4pt"> </span>2g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span><span style="letter-spacing:1.45pt;
  mso-font-width:122%"> </span><span style="letter-spacing:-.1pt">Z</span><span style="letter-spacing:-.05pt">eitpunkt</span><span style="letter-spacing:
  .25pt"> </span><span style="letter-spacing:-.05pt">der</span><span style="letter-spacing:.15pt"> </span><span style="letter-spacing:-.15pt">An</span><span style="letter-spacing:-.1pt">tibiotik</span><span style="letter-spacing:-.15pt">ag</span><span style="letter-spacing:-.1pt">abe:</span><span style="letter-spacing:.35pt"> </span><span style="letter-spacing:-.15pt">pr</span><span style="letter-spacing:-.2pt">ä</span><span style="letter-spacing:.35pt"> </span>OP
|- style="mso-yfti-irow:10"
| style="width:288.3pt;" width="384" valign="top" |Schwangerschaftsabbruch (Interruptiones und Abortabrasiones)
| style="width:260.1pt;" width="347" valign="top" |Keine PAP
|- style="mso-yfti-irow:11"
| style="width:288.3pt;" width="384" valign="top" |Implantation  von alloplastischen Material
| style="width:260.1pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">ef</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:.4pt"> </span>2g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:12;mso-yfti-lastrow:yes"
| style="width:182.8pt;" width="244" valign="top" |'''HNO/MKG-Eingriffe'''
| style="width:288.3pt;" width="384" valign="top" |<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Ausgedehnte (Tumor-)Operationen an Larynx  oder Pharynx mit/ohne Lappenrekonstruktion oder Neck Dissection
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>(Laser)-Resektion von Tumoren in Mundhöhle und  Pharynx
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Operation eines Zenker Divertikels (offen oder endo-skopisch)
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Tracheaquerresektion
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Tracheotomie, Tracheostomaverschluss
| style="width:260.1pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:-.35pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span><span style="letter-spacing:-.35pt"> </span>
 
oder  Ampicillin/Sulbactam 3g i.v.
|}
'''Cave: immer ab 120kg KG bzw. BMI > 35: Cefuroxim/Cefazolin 3g'''
 
solid windowtext .5pt;mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt"
{| class="wikitable filterable MsoTableGrid" border="1" cellspacing="0" cellpadding="0" style="margin-left:5.4pt;border-collapse:collapse;border:none;mso-border-alt:"
|+
| style="width:183.0pt;" width="244" valign="top" |Eingriffe 
| style="width:288.25pt;" width="384" valign="top" |Operationen
| style="width:259.95pt;" width="347" valign="top" |Antibiotika
|- style="height:147.9ptpx;"
| rowspan="5" style="width:183.0pt;" width="244" valign="top" |'''HNO/MKG-Eingriffe'''
| style="width:288.25pt;" width="384" valign="top" |<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Septorhinoplastik<sup>1,2</sup>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Schädelbasis OP mit<span style="letter-spacing:-.55pt"> </span><span style="letter-spacing:-.15pt">Du</span><span style="letter-spacing:-.1pt">r</span><span style="letter-spacing:-.15pt">ae</span><span style="letter-spacing:-.1pt">röffnung</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Tympanoplastik<sup>2</sup>, Stapesplastik<sup>2</sup>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Gehörgangsplastik<sup>2</sup>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Frakturversorgung von <span style="letter-spacing:-.1pt">M</span><span style="letter-spacing:-.05pt">itt</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">lg</span><span style="letter-spacing:-.1pt">esic</span><span style="letter-spacing:-.05pt">h</span><span style="letter-spacing:-.1pt">t-,  Or</span><span style="letter-spacing:-.05pt">bitaboden- oder Schädelfrakturen,  insb. mit Einbringen von Fremdmaterial<sup>1,2</sup></span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Dakryozystorhinostomie<sup>1,2</sup>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Cochlear Implantat, Implantierbare Hörgeräte, Knochenanker („bone-anchored hearing  aid“, Epithesen, dentale Implantate)
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Abszess-Tonsillektomie (ggf. als AB-Therapie!) <sup>1</sup>
| style="width:259.95pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.15pt">efaz</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:-.8pt"> </span>2g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
 
oder Ampicillin/Sulbactam 3g i.v.
 
 
 
<sup>1</sup>ggf. + Metronidazol 0,5g i.v.  (Anaerobier, bei Eröffnung von Schleimhaut)
 
<sup>2</sup>fakultative Antibiotikagabe
|- style="mso-yfti-irow:2"
| style="width:288.25pt;" width="384" valign="top" |<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Septumplastik, Conchotomie, NNH-OP <span style="letter-spacing:-.1pt">(o</span><span style="letter-spacing:-.05pt">hne  Inf</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:
  -.05pt">ktion)</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Adenotomie, Tonsillektomie, Tonsillotomie
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Posteriore Chordektomie
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>geschlossene Nasenbeinreposition
 
<span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
  mso-bidi-font-family:Symbol;letter-spacing:-.1pt;mso-ansi-language:EN-US;
  mso-bidi-font-weight:bold"><span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">    </span></span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-bidi-font-family:
  Arial;letter-spacing:-.15pt;mso-ansi-language:EN-US;mso-bidi-font-weight:
  bold">P</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-bidi-font-family:Arial;letter-spacing:-.1pt;mso-ansi-language:EN-US;
  mso-bidi-font-weight:bold">arotidektomie (lateral u. total),  Submandibulektomie</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Exstirpation von Halszysten o. Lymphknoten
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Neck-Dissection (isoliert, ein-  oder beidseitig)*
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>kleine Stimmbandchirurgie
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>kleinere Schleimhauteingriffe (Fibrom,  Papillom, etc.)
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Anthelixplastik/Otoplastik/Otopexie
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Parazentese, Paukendrainage
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Mikrolaryngoskopie, Ösophagoskopie,  Bronchoskopie, Pharyngoskopie
| style="width:259.95pt;" width="347" valign="top" |Keine PAP
 
„clean“
 
<nowiki>*</nowiki>bei extensiver Lymphadenektomie fakultative Antibiotikagabe
|- style="mso-yfti-irow:3"
| colspan="2" style="width:548.2pt;" width="731" valign="top" |''Alternative bei  ß-Laktam-Allergie'': Clindamycin 600mg  (900mg bei KG > 80kg) i.v. über 30 min
|- style="mso-yfti-irow:4"
| colspan="2" style="width:548.2pt;" width="731" valign="top" |Es  gibt keine Evidenz für positive Effekte einer „prolongierten perioperativen  Prophylaxe“ über mehr als 24h, auch bei HNO-Eingriffen!
 
<span style="mso-char-type:symbol;mso-symbol-font-family:
  Wingdings">à</span> KEINE prophylaktische  Antibiotikagabe über mehrere Tage, selbst bei großen TU-Eingriffen
|- style="mso-yfti-irow:5;mso-yfti-lastrow:yes"
| colspan="2" style="width:548.2pt;" width="731" valign="top" |KEINE  systemische, prophylaktische Antibiotikatherapie bei Nasentamponade (insb.  bei NT <3 Tage)
|}
'''Cave: immer ab 120kg KG bzw. BMI > 35: Cefuroxim/Cefazolin 3g'''
{| class="wikitable filterable MsoTableGrid" style="width:731.45pt;" border="1" cellspacing="0" cellpadding="0" width="975"
|+
| style="width:183.0pt;" width="244" valign="top" |Eingriffe
| style="width:288.25pt;" width="384" valign="top" |Operationen
| style="width:260.2pt;" width="347" valign="top" |Antibiotika
|- style="mso-yfti-irow:1"
| rowspan="3" style="width:183.0pt;" width="244" valign="top" |'''Neurochirurgische  Eingriffe'''
| style="width:288.25pt;" width="384" valign="top" |Liquor-Shunt-Operationen, ICP-Sonde
| style="width:260.2pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.15pt">efaz</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:-.8pt"> </span>2g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:2"
| style="width:288.25pt;" width="384" valign="top" |Spinalchirurgie
| style="width:260.2pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.15pt">efaz</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:-.8pt"> </span>2g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:3"
| style="width:288.25pt;" width="384" valign="top" |Kraniotomie; <span style="letter-spacing:.15pt"><span style="mso-spacerun:yes"> </span></span><span style="letter-spacing:-.15pt">K</span><span style="letter-spacing:-.1pt">raniopl</span><span style="letter-spacing:-.15pt">ast</span><span style="letter-spacing:-.1pt">ik</span>
| style="width:260.2pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.15pt">efaz</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:-.8pt"> </span>2g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span>
|- style="mso-yfti-irow:4"
| style="width:183.0pt;" width="244" valign="top" |'''Ophthalmologische Eingriffe'''
| style="width:288.25pt;" width="384" valign="top" |Penetrierende, perforierende Verletzungen
| style="width:260.2pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">ef</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:.4pt"> </span>2g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:5"
| rowspan="7" style="width:183.0pt;" width="244" valign="top" |'''Orthopädisch-/Traumatologisch-  / Handchirurgische Eingriffe'''
| style="width:288.25pt;" width="384" valign="top" |Große Gelenkendoprothesen (Knie, Hüfte, Schulter)
| style="width:260.2pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">ef</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:.4pt"> </span>2g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:6"
| style="width:288.25pt;" width="384" valign="top" |Wirbelsäulenchirurgie
| style="width:260.2pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">ef</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:.4pt"> </span>2g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:7"
| style="width:288.25pt;" width="384" valign="top" |Offene und größere athroskopische Gelenkeingriffe (z.B. Kreuzbandplastik)
| style="width:260.2pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">ef</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:.4pt"> </span>2g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:8"
| style="width:288.25pt;" width="384" valign="top" |Kleine <span style="letter-spacing:-.05pt">arthr</span><span style="letter-spacing:-.1pt">os</span><span style="letter-spacing:-.05pt">kopis</span><span style="letter-spacing:-.1pt">c</span><span style="letter-spacing:-.05pt">he</span>  <span style="letter-spacing:-.15pt">Ope</span><span style="letter-spacing:
  -.1pt">rationen</span>
| style="width:260.2pt;" width="347" valign="top" |Keine PAP
|- style="mso-yfti-irow:9"
| style="width:288.25pt;" width="384" valign="top" |Offene Frakturen mit  Weichteilschaden/ schwere Hand-verletzungen mit<span style="letter-spacing:.6pt"> </span><span style="letter-spacing:
  -.1pt">Gewebsz</span><span style="letter-spacing:-.05pt">err</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">i</span><span style="letter-spacing:-.1pt">ß</span><span style="letter-spacing:-.05pt">ungen,</span><span style="letter-spacing:1.45pt;mso-font-width:117%"> </span><span style="letter-spacing:-.1pt;mso-font-width:105%">Glied</span><span style="letter-spacing:-.05pt;mso-font-width:105%">m</span><span style="letter-spacing:-.1pt;mso-font-width:105%">aße</span><span style="letter-spacing:-.05pt;mso-font-width:105%">nrepl</span><span style="letter-spacing:-.1pt;mso-font-width:105%">an</span><span style="letter-spacing:-.05pt;mso-font-width:105%">tation*</span>
| style="width:260.2pt;" width="347" valign="top" |Cefuroxim 1,5g <span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span> +/- <span style="letter-spacing:-.15pt">Me</span><span style="letter-spacing:-.1pt">tr</span><span style="letter-spacing:-.15pt">o</span><span style="letter-spacing:-.1pt">nid</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">ol</span> 0,5g <span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span> (je nach Verschmutzungsgrad der Wunde)
 
''*<span style="letter-spacing:-.65pt"> Bei </span><span style="letter-spacing:-.1pt">primär</span><span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-.1pt">n</span><span style="letter-spacing:-.65pt"> </span><span style="letter-spacing:-.1pt">W</span><span style="letter-spacing:-.05pt">undv</span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">r</span><span style="letter-spacing:-.1pt">sc</span><span style="letter-spacing:-.05pt">hluss</span><span style="letter-spacing:-.65pt"> </span><span style="letter-spacing:-.05pt">nur</span><span style="letter-spacing:-.65pt"> </span><span style="letter-spacing:-.2pt">PAP</span><span style="letter-spacing:-.65pt"> </span><span style="letter-spacing:-.05pt">und</span><span style="letter-spacing:-.65pt"> </span>keine'' ''Therapie, da keine Infektion, nur'' ''Besiedlung'' ''vorliegt.'' ''Beistark'' ''kontaminierten,'' ''septischenWunden,'' ''z.T.'' ''sekundären Wunden'' ''(siehe'' ''Wundklassifikation),schweren'' ''Handverletzungenmit<span style="letter-spacing:-1.15pt"> </span><span style="letter-spacing:
  -.15pt">Ge</span><span style="letter-spacing:-.1pt">w</span><span style="letter-spacing:-.15pt">e</span><span style="letter-spacing:-.1pt">b</span><span style="letter-spacing:-.15pt">sze</span><span style="letter-spacing:-.1pt">rr</span><span style="letter-spacing:-.15pt">eiß</span><span style="letter-spacing:-.1pt">un</span><span style="letter-spacing:-.15pt">ge</span><span style="letter-spacing:-.1pt">n</span><span style="letter-spacing:-1.15pt"> </span><span style="letter-spacing:-.05pt">und</span><span style="letter-spacing:-1.1pt"> </span><span style="letter-spacing:-.05pt">-que</span><span style="letter-spacing:-.1pt">tsc</span><span style="letter-spacing:-.05pt">hun</span><span style="letter-spacing:-.1pt">ge</span><span style="letter-spacing:-.05pt">n,</span><span style="letter-spacing:-1.15pt"> </span><span style="letter-spacing:-.1pt">Glied</span><span style="letter-spacing:-.05pt">m</span><span style="letter-spacing:-.1pt">aße</span><span style="letter-spacing:-.05pt">nrepl</span><span style="letter-spacing:-.1pt">an</span><span style="letter-spacing:-.05pt">tation,</span><span style="letter-spacing:-1.1pt">  </span>ist<span style="letter-spacing:-1.15pt"> </span><span style="letter-spacing:-.1pt">tr</span><span style="letter-spacing:-.15pt">otz</span> entsprechenderchirurgischer'' ''Erfahrung'' ''eine kalkulierteAntibiotika-Therapie'' ''zu<span style="letter-spacing:
  -1.05pt"> </span><span style="letter-spacing:-.1pt">e</span><span style="letter-spacing:-.05pt">rw</span><span style="letter-spacing:-.1pt">äge</span><span style="letter-spacing:-.05pt">n</span>''
|- style="mso-yfti-irow:10"
| style="width:288.25pt;" width="384" valign="top" |Geschlossene Frakturen mit<span style="letter-spacing:.15pt"> </span><span style="letter-spacing:-.05pt">Implantat</span><span style="letter-spacing:
  -.1pt">e</span><span style="letter-spacing:-.05pt">n</span>
| style="width:260.2pt;" width="347" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">ef</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:.4pt"> </span>2g<span style="letter-spacing:.4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:11"
| style="width:288.25pt;" width="384" valign="top" |Major Amputationen (Extremitäten)
| style="width:260.2pt;" width="347" valign="top" |Cefuroxim 1,5g <span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span> + <span style="letter-spacing:-.15pt">Me</span><span style="letter-spacing:-.1pt">tr</span><span style="letter-spacing:-.15pt">o</span><span style="letter-spacing:-.1pt">nid</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">ol</span> 0,5g  <span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:
  -.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:12"
| rowspan="3" style="width:183.0pt;" width="244" valign="top" |'''Dermatologische  Eingriffe<span style="mso-spacerun:yes">  </span>'''
| colspan="2" style="width:548.45pt;" width="731" valign="top" |Die Indikation zur PAP  (perioperative Antibiotikaprophylaxe) in der Dermatochirurgie ist gegeben bei  Wunden der Klasse II-IV nach Haas und Grekin:
 
<span style="mso-list:Ignore">II. <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span>Leicht kontaminierte Wunden: kleinere Defizite der  Asepsis oder jede Operation an Mukosa oder intertriginösen Arealen (z. B.  Mundhöhle, Nasenschleimhaut, Achsel, Inguinal, Perineum). Infektionsrate etwa  10%.
 
<span style="mso-list:Ignore">III. <span style="font:7.0pt &quot;Times New Roman&quot;">   </span></span>Kontaminierte Wunden: deutliches Defizit der Asepsis  oder sichtbar entzündete Haut mit oder ohne Exsudat (z. B. entzündete Zysten,  traumatische Wunden). Infektionsrisiko 20-30%
 
<span style="mso-list:Ignore">IV. <span style="font:7.0pt &quot;Times New Roman&quot;">   </span></span>Septische Wunden: kontaminierte Fremdkörper, Eiter,  Nekrose (z. B. nekrotische Tumore, rupturierte Zysten, Acne inversa). Infektionsrisiko  etwa 40%.
|- style="mso-yfti-irow:13"
| style="width:288.25pt;" width="384" valign="top" |Große Tumorchirurgie
| style="width:260.2pt;" width="347" valign="top" |Cefuroxim 1,5g i.v.;
 
Cefazolin 2g i.v.
|- style="height:19.7ptpx;"
| style="width:288.25pt;" width="384" valign="top" |Haut- und Weichteilchirurgie
| style="width:260.2pt;" width="347" valign="top" |Cefalexin 2 g p.o.
 
<span style="color: black">Amo</span><span style="color: black">xicillin</span><span style="color: black"> </span><span style="color: black">+ <span style="letter-spacing:-.15pt">Clav</span><span style="letter-spacing:-.1pt">ul</span><span style="letter-spacing:-.15pt">ans</span><span style="letter-spacing:-.1pt">äur</span><span style="letter-spacing:-.15pt">e</span> <span style="letter-spacing:-.1pt">8</span><span style="letter-spacing:-.15pt">75/12</span><span style="letter-spacing:-.1pt">5m</span><span style="letter-spacing:-.15pt">g</span> <span style="letter-spacing:-.05pt">p.o.</span></span>
|}
'''<span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;background:yellow;mso-highlight:yellow;mso-ansi-language:
EN-US;mso-fareast-language:DE">Cave: immer ab 120kg KG bzw. BMI > 35: Cefuroxim/Cefazolin 3g</span>'''
 
solid windowtext .5pt;mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt"
{| class="wikitable filterable MsoTableGrid" border="1" cellspacing="0" cellpadding="0" style="margin-left:5.4pt;border-collapse:collapse;border:none;mso-border-alt:"
|+
| style="width:182.9pt;" width="244" valign="top" |Eingriffe 
| style="width:288.05pt;" width="384" valign="top" |Operationen
| style="width:260.25pt;" width="347" valign="top" |Antibiotika
|- style="mso-yfti-irow:1"
| rowspan="5" style="width:182.9pt;" width="244" valign="top" |'''Endo-Urologische  Eingriffe'''
| style="width:288.05pt;" width="384" valign="top" |Ureterorenoskopie
| style="width:260.25pt;" width="347" valign="top" |nur  Risikopatienten (komplizierter Ureterstein; langfristig einliegender  Katheter)
 
<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-ansi-language:
  EN-US">Cefuroxim 1,5g i.v.</span>
|- style="mso-yfti-irow:2"
| style="width:288.05pt;" width="384" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-ansi-language:EN-US;font-weight:normal">Percutane Nephrolitholapaxie</span>
| style="width:260.25pt;" width="347" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-ansi-language:
  EN-US">Cefuroxim 1,5g i.v.</span>
|- style="mso-yfti-irow:3"
| style="width:288.05pt;" width="384" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-ansi-language:EN-US;font-weight:normal">Blasensteinlithotripsie</span>
| style="width:260.25pt;" width="347" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-ansi-language:
  EN-US">Cefuroxim 1,5g i.v.</span>
|- style="mso-yfti-irow:4"
| style="width:288.05pt;" width="384" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-ansi-language:EN-US;font-weight:normal">TUR-P (außer „low risk/ small  size“)</span>
| style="width:260.25pt;" width="347" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-ansi-language:
  EN-US">Ceftriaxon 2g i.v.</span>
|- style="mso-yfti-irow:5"
| style="width:288.05pt;" width="384" valign="top" |TUR-B; Urethrotomie; ESWL (unauffälliger Urinbefund  obligat)
| style="width:260.25pt;" width="347" valign="top" |keine PAP
|- style="mso-yfti-irow:6"
| rowspan="3" style="width:182.9pt;" width="244" valign="top" |'''Urologische Diagnostische Eingriffe'''
| style="width:288.05pt;" width="384" valign="top" |Prostatabiopsie transrektal
| style="width:260.25pt;" width="347" valign="top" |Fosfomycin 3 g oral; cave: Aufklärung über nicht  gegebene arzneimittelrechtliche Zulassung
 
Alternativ in Ausnahmefällen:
 
Mit expliziter Risikoaufklärung weiterhin  Ciprofloxacin 500mg p.o.
 
Ceftriaxon 2g i.v. und postinterventionell für 2 Tage Cefpodoxim 2 x 200 mg  p.o.
 
Bei Z.n. vorausgegangenen transrektalen  Prostatabiopsien: Rektalabstrich und ggf. testgerechte Antibiose nach Befund
|- style="mso-yfti-irow:7"
| style="width:288.05pt;" width="384" valign="top" |<span style="color: black">Prostatabiopsie perineal</span>
| style="width:260.25pt;" width="347" valign="top" |<span style="color: black">Cefuroxim 1,5g i.v.</span>
|- style="mso-yfti-irow:8"
| style="width:288.05pt;" width="384" valign="top" |Zystoskopie; Urodynamik; diag. URS (unauffälliger  mikrobiologischer Urinbefund obligat)
| style="width:260.25pt;" width="347" valign="top" |Keine PAP
|- style="height:27.95ptpx;"
| rowspan="3" style="width:182.9pt;" width="244" valign="top" |'''Laparoskopische  Eingriffe'''
| style="width:288.05pt;" width="384" valign="top" |ohne Eröffnung + Rekonstruktion Harntrakt: z.B.  Nephrektomie, Adrenalektomie
| style="width:260.25pt;" width="347" valign="top" |Keine PAP
|- style="height:41.85ptpx;"
| style="width:288.05pt;" width="384" valign="top" |mit Eröffnung + Rekonstruktion Harntrakt: z.B.  radikale Prostatektomie, Nierenbeckenplastik, Nierenteilresektion,  Ureterozystoneostomie, …
| style="width:260.25pt;" width="347" valign="top" |Cefuroxim  1,5g i.v.
|- style="height:36.2ptpx;"
| style="width:288.05pt;" width="384" valign="top" |Zystektomie
| style="width:260.25pt;" width="347" valign="top" |Cefuroxim  1,5g i.v. (je nach OP-Zeit ggf. wiederholt); bei Verwendung Dickdarm zur  Harnableitung + Metronidazol 0,5g i.v.
|}
'''Cave: immer ab 120kg KG bzw. BMI > 35: Cefuroxim/Cefazolin 3g'''
 
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{| class="wikitable filterable MsoTableGrid" border="1" cellspacing="0" cellpadding="0" style="margin-left:5.4pt;border-collapse:collapse;border:none;mso-border-alt:"
|+
| style="width:182.85pt;" width="244" valign="top" |Eingriffe 
| style="width:288.05pt;" width="384" valign="top" |Operationen
| style="width:260.3pt;" width="347" valign="top" |Antibiotika
|- style="height:25.15ptpx;"
| rowspan="3" style="width:182.85pt;" width="244" valign="top" |'''Urologische offene Eingriffe'''
| style="width:288.05pt;" width="384" valign="top" |ohne  Eröffnung + Rekonstruktion Harntrakt: z.B. Nephrektomie, Adrenalektomie
| style="width:260.3pt;" width="347" valign="top" |Keine PAP
|- style="height:35.45ptpx;"
| style="width:288.05pt;" width="384" valign="top" |mit  Eröffnung + Rekonstruktion Harntrakt: z.B. radikale Prostatektomie,  Nierenbeckenplastik, Nierenteilresektion, Ureterozystoneostomie, …
| style="width:260.3pt;" width="347" valign="top" |Cefuroxim 1,5g i.v.
|- style="height:40.25ptpx;"
| style="width:288.05pt;" width="384" valign="top" |Zystektomie
| style="width:260.3pt;" width="347" valign="top" |Cefuroxim 1,5g i.v. (je nach Op-Zeit  ggf. wiederholt); bei Verwendung Dickdarm zur Harnableitung und Metronidazol  0,5g i.v.
|- style="mso-yfti-irow:4;mso-yfti-lastrow:yes"
| style="width:182.85pt;" width="244" valign="top" |'''CAPD-Katheter'''
| style="width:288.05pt;" width="384" valign="top" |Implantation
| style="width:260.3pt;" width="347" valign="top" |Vancomycin  1x15mg/kg KG
|}
'''<span style="mso-spacerun:yes">  </span>Cave:''' Kontraindikationen bei Chinolonen beachten. Erregernachweis heranziehen, danach AB-Entscheidung.
 
'''Multi- und panresistente Erreger (MRE)<span style="letter-spacing:-1.45pt"> </span><span style="letter-spacing:-.15pt">z.B</span><span style="letter-spacing:-.1pt">.</span><span style="letter-spacing:-1.45pt"> </span><span style="letter-spacing:-.15pt">MRSA</span><span style="letter-spacing:-.1pt">-,</span><span style="letter-spacing:-1.45pt"> </span><span style="letter-spacing:-.1pt">MRGN-Be</span><span style="letter-spacing:-.05pt">siedlun</span><span style="letter-spacing:-.1pt">g</span>'''
 
'''Indikation'''
 
Nach <span style="letter-spacing:-.05pt">den</span> <span style="letter-spacing:-.05pt">Empfehlungen</span> <span style="letter-spacing:-.1pt">der</span> <span style="letter-spacing:-.05pt">geplanten</span> <span style="letter-spacing:-.1pt">Prozedur. Anpassung der PAP in Abhängigkeit von Erreger, Resistenz, Wirtsfaktoren, geplanter OP und Lokalisation des Erregerreservoirs:</span>
 
solid windowtext .5pt;mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt"
{| class="wikitable filterable MsoTableGrid" border="1" cellspacing="0" cellpadding="0" style="margin-left:5.4pt;border-collapse:collapse;border:none;mso-border-alt:"
|+
| style="width:184.3pt;" width="246" valign="top" |MRSA-Besiedlung
| style="width:552.8pt;" width="737" valign="top" |Grundsätzlich ist bei bekanntem  MRSA ein Sanierungsversuch erforderlich;
 
Vancomycin 1g<span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span><span style="letter-spacing:.25pt"> </span>zu<span style="letter-spacing:.25pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">ef</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:.3pt"> </span>/<span style="letter-spacing:.25pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">efuroxim</span><span style="letter-spacing:.3pt">  </span>+/-<span style="letter-spacing:.25pt"> </span><span style="letter-spacing:
  -.15pt">Me</span><span style="letter-spacing:-.1pt">tronid</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">ol</span>
|- style="mso-yfti-irow:1"
| style="width:184.3pt;" width="246" valign="top" |3-MRGN-Besiedlung
| style="width:552.8pt;" width="737" valign="top" |Rücksprache Mikrobiologie, ABS-Team
|- style="mso-yfti-irow:2;mso-yfti-lastrow:yes"
| style="width:184.3pt;" width="246" valign="top" |4-MRGN-Besiedlung
| style="width:552.8pt;" width="737" valign="top" |Rücksprache Mikrobiologie, ABS-Team
|}
'''PAP''' '''bei<span style="letter-spacing:.7pt"> </span><span style="letter-spacing:-.15pt">Alle</span><span style="letter-spacing:-.1pt">rgie</span><span style="letter-spacing:.9pt"> </span><span style="letter-spacing:-.2pt">gege</span><span style="letter-spacing:-.15pt">n</span><span style="letter-spacing:.9pt"> </span><span style="letter-spacing:-.15pt">Be</span><span style="letter-spacing:-.1pt">ta-Laktam-</span><span style="letter-spacing:-.15pt">An</span><span style="letter-spacing:-.1pt">tibiotik</span><span style="letter-spacing:-.15pt">a</span>'''
 
'''Cave'''
 
Symptome einer <span style="letter-spacing:-.05pt">berichteten</span> Penicillin-Allergie <span style="letter-spacing:-.05pt">genau</span> <span style="letter-spacing:-.05pt">erfragen.</span> Eine Kreuzallergie zu Cephalosporinen ist se<span style="letter-spacing:-.05pt">lten.</span> Es ist <span style="letter-spacing:-.05pt">schwierig,</span> <span style="letter-spacing:
-.05pt">belastbare</span> <span style="letter-spacing:.05pt">Zahlen</span> <span style="letter-spacing:-.05pt">über</span> das <span style="letter-spacing:-.05pt">Ausmaß</span> <span style="letter-spacing:-.1pt">der</span> Kreuzallergie zu finden, <span style="letter-spacing:-.05pt">wohl</span> <span style="letter-spacing:-.05pt">auch</span> <span style="letter-spacing:-.05pt">weil</span> das<span style="letter-spacing:
4.6pt"> </span><span style="letter-spacing:-.05pt">Ausmaß</span> <span style="letter-spacing:-.1pt">der</span> Kreuzallergie <span style="letter-spacing:
-.05pt">mit</span> <span style="letter-spacing:-.05pt">dem</span> <span style="letter-spacing:-.05pt">Ausmaß</span> <span style="letter-spacing:-.1pt">der</span> <span style="letter-spacing:.05pt">chemischen</span> Modifikation <span style="letter-spacing:-.1pt">der</span> Substanz abnimmt. Daher würde <span style="letter-spacing:-.05pt">eher</span> <span style="letter-spacing:.05pt">ein</span> <span style="letter-spacing:-.25pt">Zweit-</span> (Cefuroxim) <span style="letter-spacing:.05pt">als</span> <span style="letter-spacing:.05pt">ein</span> <span style="letter-spacing:-.05pt">Erstgenerations-Cephalosporin</span> (Cefazolin) zu <span style="letter-spacing:-.05pt">empfehlen</span> sein. Bei Vorliegen einer IgE vermittelten Penicillin-Allergie, z.B: Anaphylaxie, Urticaria, Bronchospasmen, bei einer exfoliativen Dermatitis oder bei lebensbedrohlichen verzögerten Hypersensitivitätsreaktionen (u.a. DRESS, hämolytische Anämie, exfoliative Dermatitis, etc.) sollten keine ß-Lactam Antibiotika gegeben werden.
 
solid windowtext .5pt;mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt"
{| class="wikitable filterable MsoTableGrid" border="1" cellspacing="0" cellpadding="0" style="margin-left:5.4pt;border-collapse:collapse;border:none;mso-border-alt:"
|+
| style="width:248.1pt;" width="331" valign="top" |'''Empfohlene Antibiotika'''
| style="width:276.4pt;" width="369" valign="top" |Alternative
|- style="mso-yfti-irow:1"
| style="width:248.1pt;" width="331" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:
  -.2pt">i.</span><span style="letter-spacing:-.25pt">v</span><span style="letter-spacing:-.2pt">.;</span><span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.15pt">efaz</span><span style="letter-spacing:-.1pt">olin</span><span style="letter-spacing:-.8pt"> </span>2g<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
| style="width:276.4pt;" width="369" valign="top" |Clindamycin 600<span style="letter-spacing:
  -.05pt">m</span><span style="letter-spacing:-.1pt">g</span><span style="letter-spacing:-.7pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:2;mso-yfti-lastrow:yes"
| style="width:248.1pt;" width="331" valign="top" |Cefuroxim 1,5g<span style="letter-spacing:.8pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span><span style="letter-spacing:.75pt"> </span>+<span style="letter-spacing:.8pt"> </span><span style="letter-spacing:-.15pt">Me</span><span style="letter-spacing:-.1pt">tronid</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">ol</span><span style="letter-spacing:.8pt"> </span><span style="letter-spacing:-.05pt">500m</span><span style="letter-spacing:-.1pt">g</span><span style="letter-spacing:.75pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
| style="width:276.4pt;" width="369" valign="top" |Ciprofloxacin 400mg i.v. +<span style="letter-spacing:.9pt"> </span><span style="letter-spacing:-.15pt">Me</span><span style="letter-spacing:-.1pt">tronid</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">ol</span><span style="letter-spacing:.95pt"> </span><span style="letter-spacing:-.05pt">500m</span><span style="letter-spacing:-.1pt">g</span><span style="letter-spacing:.9pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|}
'''Penicillin-Allergie'''
 
Siehe Arbeitshilfe Penicillin-Allergie – hier klicken
 
'''Endokarditis-Prophylaxe'''
 
'''Grundlage:'''
 
===<span style="font-size:10.0pt; font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family:Symbol; mso-ansi-language:EN-US;font-weight:normal"><span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif; letter-spacing:-.15pt;mso-ansi-language:EN-US;font-weight:normal">2015 ESC Guidelines for the management of infective Endocarditis</span>===
<span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol;mso-ansi-language:EN-US;mso-fareast-language:DE"><span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
letter-spacing:-.2pt;mso-ansi-language:EN-US">Task</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-ansi-language:
EN-US"> <span style="letter-spacing:-.1pt">force</span> for the Management <span style="letter-spacing:-.1pt">of</span> Infective Endocarditis <span style="letter-spacing:-.1pt">of</span> the European <span style="letter-spacing:
.05pt">Society</span> <span style="letter-spacing:-.1pt">of</span><span style="letter-spacing:3.65pt"> </span><span style="letter-spacing:-.05pt">Cardiology</span></span>
 
'''Wer:'''
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span>wird nur für Hochrisikopatienten empfohlen
 
Hochrisikopatienten sind <span style="letter-spacing:-.1pt">Patienten</span> <span style="letter-spacing:-.05pt">mit</span> <span style="letter-spacing:-.1pt">der</span> höchsten <span style="letter-spacing:.05pt">Inzidenz</span> einer infektiösen <span style="letter-spacing:-.05pt">Endokarditis</span> <span style="letter-spacing:
-.2pt">und/oder</span> <span style="letter-spacing:-.05pt">mit</span><span style="letter-spacing:4.4pt"> </span><span style="letter-spacing:-.05pt">dem</span> höchsten <span style="letter-spacing:.05pt">Risiko</span> <span style="letter-spacing:.1pt">für</span> einen schlechten <span style="letter-spacing:
-.2pt">Verlauf</span> einer infektiösen <span style="letter-spacing:-.05pt">Endokarditis.</span> Dazu <span style="letter-spacing:-.05pt">gehören:</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span>Patienten mit Klappenprothesen, einschließlich Transkatheterklappen, oder mit rekonstruierten Klappen unter Verwendung prothetischen > Materials
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span>Patienten <span style="letter-spacing:-.05pt">mit</span> <span style="letter-spacing:-.05pt">überstandener</span> <span style="letter-spacing:-.05pt">Endokarditis</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span>Patienten mit angeborenen Herzfehlern:
 
<span style="mso-list:Ignore">a) <span style="font:7.0pt &quot;Times New Roman&quot;">   </span></span>jegliche zyanotischen Herzfehler
 
<span style="mso-list:Ignore">b) <span style="font:7.0pt &quot;Times New Roman&quot;">   </span></span>bis zu 6 Monate nach operativer oder interventioneller Vitienkorrektur unter Verwendung von prothetischem Material oder lebenslang bei residuellem Shunt oder Klappeninsuffizienz
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span>Keine Endokarditis-Prophylaxe <span style="letter-spacing:.1pt">für</span> alle <span style="letter-spacing:-.05pt">anderen</span> <span style="letter-spacing:-.05pt">Formen</span> <span style="letter-spacing:
-.1pt">der</span> <span style="letter-spacing:-.05pt">Klappen-</span> <span style="letter-spacing:.05pt">und</span> Herzerkrankungen
 
'''Wann''' (bei welchen Eingriffen sollten Hochrisikopatienten eine Endokarditis-Prophylaxe erhalten):
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span>Zahnärztliche Eingriffe
 
<span style="mso-list:Ignore">o <span style="font:7.0pt &quot;Times New Roman&quot;">   </span></span>Endokarditis-Prophylaxe <span style="letter-spacing:-.05pt">empfohlen</span> <span style="letter-spacing:
-.05pt">bei</span> <span style="letter-spacing:.05pt">Eingriffen</span> / <span style="letter-spacing:-.05pt">Manipulationen</span> <span style="letter-spacing:
.1pt">an</span> <span style="letter-spacing:-.1pt">der</span> <span style="letter-spacing:-.05pt">Gingiva,</span> <span style="letter-spacing:-.1pt">der</span> periapikalen<span style="letter-spacing:2.85pt"> </span><span style="letter-spacing:
.05pt">Zahnregion</span> <span style="letter-spacing:-.05pt">oder</span> <span style="letter-spacing:-.1pt">Perforation</span> <span style="letter-spacing:
-.1pt">der</span> <span style="letter-spacing:-.05pt">oralen</span> <span style="letter-spacing:-.05pt">Mukosa</span>
 
<span style="mso-list:Ignore">o <span style="font:7.0pt &quot;Times New Roman&quot;">   </span></span>KEINE <span style="letter-spacing:-.05pt">Endokarditis-Prophylaxe</span> <span style="letter-spacing:-.05pt">bei</span> <span style="letter-spacing:
-.05pt">Applikation</span> <span style="letter-spacing:-.15pt">von</span> Lokalanästhesie <span style="letter-spacing:.1pt">in</span> reizlosem <span style="letter-spacing:-.1pt">Gewebe,</span> <span style="letter-spacing:-.1pt">Faden-</span><span style="letter-spacing:2.05pt"> </span>entfernung, <span style="letter-spacing:
-.1pt">Röntgen,</span> Einsatz <span style="letter-spacing:-.05pt">oder</span> <span style="letter-spacing:-.05pt">Entfernung</span> <span style="letter-spacing:
-.15pt">von</span> Zahnprothesen <span style="letter-spacing:-.05pt">oder</span> <span style="letter-spacing:.05pt">Klammern,</span> <span style="letter-spacing:
-.05pt">Lippentrauma</span> <span style="letter-spacing:-.05pt">oder</span><span style="letter-spacing:3.75pt"> </span><span style="letter-spacing:-.1pt">Verletzung</span> <span style="letter-spacing:-.1pt">der</span> <span style="letter-spacing:-.05pt">oralen</span> <span style="letter-spacing:-.05pt">Mukosa</span>
 
<span style="mso-list:Ignore">o <span style="font:7.0pt &quot;Times New Roman&quot;">   </span></span>KEINE <span style="letter-spacing:-.05pt">Endokarditis-Prophylaxe</span> nach <span style="letter-spacing:.05pt">Milchzahnwechsel</span> <span style="letter-spacing:-.05pt">oder</span> <span style="letter-spacing:-.1pt">Verletzung</span> <span style="letter-spacing:-.1pt">der</span> <span style="letter-spacing:-.05pt">Lippen</span> <span style="letter-spacing:.05pt">und</span> <span style="letter-spacing:-.05pt">oralen</span><span style="letter-spacing:1.55pt"> </span><span style="letter-spacing:-.05pt">Mukosa</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span>Eingriffe am Respirationstrakt
 
<span style="mso-tab-count:1">        </span>'''Cave:''' KEINE <span style="letter-spacing:-.05pt">Endokarditis-Prophylaxe</span> <span style="letter-spacing:-.05pt">bei</span> Eingriffen am Respirationstrakt, einschließlich <span style="letter-spacing:-.05pt">Laryngoskopie,</span> <span style="letter-spacing:-.1pt">Bronchoskopie</span> transnasale-,
 
<span style="mso-tab-count:1">        </span><span style="letter-spacing:-.05pt">endotracheale</span> <span style="letter-spacing:
-.05pt">Intubation (oral oder nasal)</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span>Gastrointestinale oder Urogenitale Eingriffe an infizierten Herden
 
<span style="mso-list:Ignore">o <span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>intraabdominaler Abszess
 
<span style="mso-list:Ignore">o <span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Ileus
 
<span style="mso-list:Ignore">o <span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Darmperforation
 
<span style="mso-list:Ignore">o <span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Magenperforation
 
<span style="mso-list:Ignore">o <span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Cholecystitis/ Gallenblasenempyem
 
<span style="mso-list:Ignore">o <span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>Fourniersche Gangrän
 
<span style="mso-list:Ignore">o <span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>infizierte Harnstauungsniere
 
'''<span style="mso-tab-count:1">             </span>Cave:''' KEINE <span style="letter-spacing:-.05pt">Endokarditis-Prophylaxe</span> <span style="letter-spacing:-.05pt">bei</span><span style="letter-spacing:.05pt">:</span> <span style="letter-spacing:-.1pt">Gastroskopie,</span> <span style="letter-spacing:
-.15pt">Coloskopie,</span> transösophageales<span style="letter-spacing:3.85pt"> </span><span style="letter-spacing:-.1pt">Echo,</span> <span style="letter-spacing:
-.1pt">Cystoskopie</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span>Eingriffe an Weichteilgewebe und Haut
 
<span style="mso-list:Ignore">o <span style="font:7.0pt &quot;Times New Roman&quot;">  </span></span>KEINE <span style="letter-spacing:-.05pt">Endokarditis-Prophylaxe</span>
 
'''PAP und Endokarditis-Prophylaxe'''
 
Liegt eine Indikation zur Endokarditis-Prophylaxe vor, <span style="letter-spacing:
-.1pt">werden</span> - anstelle <span style="letter-spacing:-.1pt">der</span> oben <span style="letter-spacing:-.05pt">empfohlenen</span> Antibiotika – <span style="letter-spacing:-.05pt">bevorzugt</span> Substanzen <span style="letter-spacing:-.05pt">mit</span> <span style="letter-spacing:-.05pt">Enterokokken-Wirksamkeit</span> eingesetzt:
{| class="wikitable filterable MsoTableGrid" style="width:26.0cm;" border="1" cellspacing="0" cellpadding="0" width="983"
|+
| style="width:262.25pt;" width="350" valign="top" |'''Antibiotika zur PAP'''
| style="width:474.85pt;" width="633" valign="top" |Empfohlene  (Ersatz-) Substanz bei Indikation zur Endokarditis-Prophylaxe
|- style="mso-yfti-irow:1"
| style="width:262.25pt;" width="350" valign="top" |Ohne <span style="letter-spacing:-.15pt">P</span><span style="letter-spacing:-.1pt">AP-Indikation</span>
| style="width:474.85pt;" width="633" valign="top" |Ampicillin 2g<span style="letter-spacing:1.5pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|- style="mso-yfti-irow:2"
| style="width:262.25pt;" width="350" valign="top" |Cefazolin /<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">efuroxim</span>
| style="width:474.85pt;" width="633" valign="top" |<span style="font-size:10.0pt;
  font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-font-width:105%;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">Ampicillin-</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;
  mso-font-width:105%;mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:
  bold">Sulbac</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.05pt;mso-font-width:105%;mso-ansi-language:EN-US;font-weight:
  normal;mso-bidi-font-weight:bold">t</span><span style="font-size:10.0pt;
  font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;mso-font-width:105%;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">am</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.3pt;
  mso-font-width:105%;mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:
  bold"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-font-width:105%;mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:
  bold">3g<span style="letter-spacing:-.35pt"> </span><span style="letter-spacing:
  -.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span></span>
|- style="mso-yfti-irow:3;mso-yfti-lastrow:yes"
| style="width:262.25pt;" width="350" valign="top" |Cefazolin /<span style="letter-spacing:-1.55pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.15pt">ef</span><span style="letter-spacing:-.1pt">ur</span><span style="letter-spacing:-.15pt">o</span><span style="letter-spacing:-.1pt">xi</span><span style="letter-spacing:-.15pt">m</span><span style="letter-spacing:-1.6pt"> </span>+<span style="letter-spacing:-1.55pt"> </span><span style="letter-spacing:-.15pt">Me</span><span style="letter-spacing:-.1pt">tr</span><span style="letter-spacing:-.15pt">o</span><span style="letter-spacing:-.1pt">nid</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">ol</span>
| style="width:474.85pt;" width="633" valign="top" |<span style="font-size:10.0pt;
  font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-font-width:105%;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">Ampicillin-</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;
  mso-font-width:105%;mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:
  bold">Sulbac</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.05pt;mso-font-width:105%;mso-ansi-language:EN-US;font-weight:
  normal;mso-bidi-font-weight:bold">t</span><span style="font-size:10.0pt;
  font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;mso-font-width:105%;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">am</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.35pt;
  mso-font-width:105%;mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:
  bold"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-font-width:105%;mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:
  bold">3g<span style="letter-spacing:-.35pt"> </span><span style="letter-spacing:
  -.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span></span>
|}
{| class="wikitable filterable MsoTableGrid" style="width:26.0cm;" border="1" cellspacing="0" cellpadding="0" width="983"
|+
| style="width:262.25pt;" width="350" valign="top" |'''ß-Laktam-Allergie'''
| style="width:474.85pt;" width="633" valign="top" |Empfohlene  (Ersatz-) Substanz bei Indikation zur Endokarditis-Prophylaxe
|- style="mso-yfti-irow:1"
| style="width:262.25pt;" width="350" valign="top" |Ohne <span style="letter-spacing:-.15pt">P</span><span style="letter-spacing:-.1pt">AP</span>
| style="width:474.85pt;" width="633" valign="top" |<span style="font-size:10.0pt;
  font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;mso-ansi-language:EN-US;
  font-weight:normal;mso-bidi-font-weight:bold">Cli</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">ndam</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">y</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">cin</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:1.7pt;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">600m</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">g</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:1.7pt;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">i.</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">v</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">./p.o.</span>
|- style="mso-yfti-irow:2"
| style="width:262.25pt;" width="350" valign="top" |Cefazolin /<span style="letter-spacing:-.8pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">efuroxim (ohne Gastrointestinaltrakt)</span>
| style="width:474.85pt;" width="633" valign="top" |<span style="font-size:10.0pt;
  font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;mso-font-width:105%;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">Cli</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;
  mso-font-width:105%;mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:
  bold">nd</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.1pt;mso-font-width:105%;mso-ansi-language:EN-US;font-weight:
  normal;mso-bidi-font-weight:bold">amyci</span><span style="font-size:10.0pt;
  font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-font-width:105%;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">n</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.65pt;
  mso-font-width:105%;mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:
  bold"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.05pt;mso-font-width:105%;mso-ansi-language:EN-US;font-weight:
  normal;mso-bidi-font-weight:bold">600m</span><span style="font-size:10.0pt;
  font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;mso-font-width:105%;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">g</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.6pt;
  mso-font-width:105%;mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:
  bold"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.15pt;mso-font-width:105%;mso-ansi-language:EN-US;font-weight:
  normal;mso-bidi-font-weight:bold">i.</span><span style="font-size:10.0pt;
  font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;mso-font-width:105%;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">v</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt;
  mso-font-width:105%;mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:
  bold">./p.</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.2pt;mso-font-width:105%;mso-ansi-language:EN-US;font-weight:
  normal;mso-bidi-font-weight:bold">o</span><span style="font-size:10.0pt;
  font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt;mso-font-width:105%;
  mso-ansi-language:EN-US;font-weight:normal;mso-bidi-font-weight:bold">.</span>
|- style="mso-yfti-irow:3;mso-yfti-lastrow:yes"
| style="width:262.25pt;" width="350" valign="top" |Cefazolin /<span style="letter-spacing:-1.55pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.15pt">ef</span><span style="letter-spacing:-.1pt">ur</span><span style="letter-spacing:-.15pt">o</span><span style="letter-spacing:-.1pt">xi</span><span style="letter-spacing:-.15pt">m</span><span style="letter-spacing:-1.6pt"> </span>+/-<span style="letter-spacing:-1.55pt"> </span><span style="letter-spacing:-.15pt">Me</span><span style="letter-spacing:-.1pt">tr</span><span style="letter-spacing:-.15pt">o</span><span style="letter-spacing:-.1pt">nid</span><span style="letter-spacing:-.15pt">az</span><span style="letter-spacing:-.1pt">ol</span>
| style="width:474.85pt;" width="633" valign="top" |Vancomycin 1g<span style="letter-spacing:
  -1.4pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span><span style="letter-spacing:-1.4pt"> </span>+<span style="letter-spacing:-1.45pt"> </span><span style="letter-spacing:-.2pt">C</span><span style="letter-spacing:-.1pt">ipr</span><span style="letter-spacing:-.15pt">ofloxacin</span><span style="letter-spacing:
  -1.4pt"> </span>400<span style="letter-spacing:-1.4pt"> </span><span style="letter-spacing:-.1pt">mg</span><span style="letter-spacing:-1.45pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span><span style="letter-spacing:-1.4pt"> </span>+/-<span style="letter-spacing:-1.4pt"> </span><span style="letter-spacing:-.15pt">Me</span><span style="letter-spacing:-.1pt">t</span><span style="letter-spacing:-.15pt">ro</span><span style="letter-spacing:-.1pt">nid</span><span style="letter-spacing:-.15pt">azol</span><span style="letter-spacing:-1.45pt"> </span>500<span style="letter-spacing:-1.4pt">  </span><span style="letter-spacing:-.1pt">mg</span><span style="letter-spacing:
  -1.45pt"> </span><span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
|}
'''Antibiotika für die perioperative Antibiotika- und Endokarditis-Prophylaxe'''
 
solid windowtext .5pt;mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt"
{| class="wikitable filterable MsoTableGrid" border="1" cellspacing="0" cellpadding="0" style="margin-left:5.4pt;border-collapse:collapse;border:none;mso-border-alt:"
|+
| style="width:132.15pt;" width="176" valign="top" |'''Antibiotikagruppe'''
| style="width:152.85pt;" width="204" valign="top" |'''Substanz'''
| style="width:127.55pt;" width="170" valign="top" |'''Dosis/Applikations-art'''
| style="width:190.0pt;" width="253" valign="top" |'''Zeitpunkt der Gabe'''
| style="width:128.65pt;" width="172" valign="top" |'''Wiederholungsgabe<sup>3)</sup>'''
|- style="mso-yfti-irow:1"
| style="width:132.15pt;" width="176" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.1pt;mso-font-width:105%">Aminope</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;
  mso-font-width:105%">nicillin</span>
| style="width:152.85pt;" width="204" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.05pt;mso-font-width:105%">Ampicillin</span>
| style="width:127.55pt;" width="170" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif">1<span style="letter-spacing:.25pt"> </span>x<span style="letter-spacing:.3pt"> </span>2g  <span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span></span>
| style="width:190.0pt;" width="253" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-fareast-font-family:Arial;mso-bidi-font-family:Arial">Infusionsende 30  min vor Schnitt</span>
| style="width:128.65pt;" width="172" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-font-width:105%">><span style="letter-spacing:-1.2pt"> </span>3<span style="letter-spacing:-1.2pt"> </span>h<span style="letter-spacing:-1.15pt"> </span><span style="letter-spacing:-.1pt">OP-Daue</span><span style="letter-spacing:-.05pt">r</span></span>
|- style="mso-yfti-irow:2"
| style="width:132.15pt;" width="176" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.1pt;mso-font-width:110%">Aminope</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;
  mso-font-width:110%">nicillin</span><span style="font-size:10.0pt;font-family:
  &quot;Verdana&quot;,sans-serif;letter-spacing:-1.05pt;mso-font-width:110%"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-font-width:110%">+<span style="letter-spacing:-1.0pt"> </span></span>
 
<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.2pt;mso-font-width:110%">ß</span><span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;mso-font-width:
  110%">-Lakt.-Inhibitor (BLI)</span>
| style="width:152.85pt;" width="204" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.1pt;mso-font-width:105%">Amo</span><span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-font-width:
  105%">xicillin</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.6pt;mso-font-width:105%"> </span><span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-font-width:105%">+<span style="letter-spacing:-.6pt"> </span><span style="letter-spacing:-.1pt">Clav</span><span style="letter-spacing:-.05pt">ulan-Säure</span></span>
 
<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.05pt;mso-font-width:105%">Ampicillin</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-1.4pt;
  mso-font-width:105%"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-font-width:105%">+<span style="letter-spacing:-1.4pt"> </span><span style="letter-spacing:-.1pt">Sulbac</span><span style="letter-spacing:-.05pt">t</span><span style="letter-spacing:-.1pt">am</span></span>
| style="width:127.55pt;" width="170" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.1pt;mso-font-width:105%">1 x 875/125mg p.o.</span>
 
<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.1pt;mso-font-width:105%">1 x 3g<span style="mso-spacerun:yes">  </span>i.v.</span>
| style="width:190.0pt;" width="253" valign="top" |120<span style="letter-spacing:.25pt"> </span><span style="letter-spacing:-.05pt">min  vor Schnitt</span><sup><span style="position:relative;top:-2.5pt;mso-text-raise:
  2.5pt">1)</span></sup>
 
Infusionsende 30 min vor Schnitt
| style="width:128.65pt;" width="172" valign="top" |><span style="letter-spacing:-1.2pt"> </span>3<span style="letter-spacing:-1.2pt"> </span>h<span style="letter-spacing:-1.15pt"> </span><span style="letter-spacing:-.1pt">OP-Daue</span><span style="letter-spacing:-.05pt">r</span>
 
><span style="letter-spacing:-1.2pt"> </span>3<span style="letter-spacing:-1.2pt"> </span>h<span style="letter-spacing:-1.15pt"> </span><span style="letter-spacing:-.1pt">OP-Daue</span><span style="letter-spacing:-.05pt">r</span>
|- style="mso-yfti-irow:3"
| style="width:132.15pt;" width="176" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.1pt">gezielte C</span><span style="font-size:10.0pt;
  font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt">arbapenem-Prophylaxe</span>
| style="width:152.85pt;" width="204" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.05pt;mso-font-width:105%">Imipe</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;
  mso-font-width:105%">ne</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.05pt;mso-font-width:105%">m <sup>2)</sup></span>
 
<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.05pt;mso-font-width:105%">Meropenem</span>
| style="width:127.55pt;" width="170" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif">1<span style="letter-spacing:.25pt"> </span>x<span style="letter-spacing:.25pt"> </span>1g<span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span></span>
 
<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.25pt">1 x 1g i.v.</span>
| style="width:190.0pt;" width="253" valign="top" |Infusionsende 30 min vor Schnitt
| style="width:128.65pt;" width="172" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-font-width:105%">><span style="letter-spacing:-1.2pt"> </span>3<span style="letter-spacing:-1.2pt"> </span>h<span style="letter-spacing:-1.15pt"> </span><span style="letter-spacing:-.1pt">OP-Daue</span><span style="letter-spacing:-.05pt">r</span></span>
|- style="mso-yfti-irow:4"
| style="width:132.15pt;" width="176" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.1pt">C</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.05pt">ephalosporin</span><span style="font-size:10.0pt;
  font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.75pt"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">Gr</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt">uppe</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.75pt">  </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif">1</span>
| style="width:152.85pt;" width="204" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.2pt">C</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.1pt">ef</span><span style="font-size:10.0pt;font-family:
  &quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt">az</span><span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">olin</span>
| style="width:127.55pt;" width="170" valign="top" |1  x 2g <span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.25pt">v</span> bei KG
 
>120<span style="letter-spacing:-.15pt">kg</span> 1 x 3g <span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span>
| style="width:190.0pt;" width="253" valign="top" |Infusionsende 30 min  vor Schnitt
| style="width:128.65pt;" width="172" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-font-width:105%">><span style="letter-spacing:-1.2pt"> </span>3<span style="letter-spacing:-1.2pt"> </span>h<span style="letter-spacing:-1.15pt"> </span><span style="letter-spacing:-.1pt">OP-Daue</span><span style="letter-spacing:-.05pt">r</span></span>
|- style="mso-yfti-irow:5;mso-yfti-lastrow:yes"
| style="width:132.15pt;" width="176" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.25pt">C</span><span style="font-size:10.0pt;font-family:
  &quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt">ephalosporin</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.9pt">  </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.15pt">Gr</span><span style="font-size:10.0pt;font-family:
  &quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">uppe</span><span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.85pt"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif">2</span>
| style="width:152.85pt;" width="204" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.15pt">Ce</span><span style="font-size:10.0pt;font-family:
  &quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">furoxim</span>
| style="width:127.55pt;" width="170" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-font-width:105%">1 x 1,5g <span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span></span>
 
<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-font-width:105%">>120<span style="letter-spacing:-.15pt">kg</span> 1 x 3g <span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span></span>
| style="width:190.0pt;" width="253" valign="top" |Infusionsende 30 min  vor Schnitt
| style="width:128.65pt;" width="172" valign="top" |<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  mso-font-width:105%">><span style="letter-spacing:-1.2pt"> </span>3<span style="letter-spacing:-1.2pt"> </span>h<span style="letter-spacing:-1.15pt"> </span><span style="letter-spacing:-.1pt">OP-Daue</span><span style="letter-spacing:-.05pt">r</span></span>
|}
'''Sonderindikationen'''
 
solid windowtext .5pt;mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt"
{| class="wikitable filterable MsoTableGrid" border="1" cellspacing="0" cellpadding="0" style="margin-left:5.4pt;border-collapse:collapse;border:none;mso-border-alt:"
|+
| style="width:139.65pt;" width="186" valign="top" |'''Antibiotikagruppe'''
| style="width:145.4pt;" width="194" valign="top" |'''Substanz'''
| style="width:127.15pt;" width="170" valign="top" |'''Dosis/Applikations-art'''
| style="width:190.2pt;" width="254" valign="top" |'''Zeitpunkt  der Gabe'''
| style="width:128.8pt;" width="172" valign="top" |'''Wiederholungsgabe<sup>3)</sup>'''
|- style="mso-yfti-irow:1"
| style="width:139.65pt;" width="186" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.25pt">C</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt">ephalosporin</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.95pt">  </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.15pt">Gr</span><span style="font-size:10.0pt;font-family:
  &quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">uppe</span><span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.95pt"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">3a</span>
| style="width:145.4pt;" width="194" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt">Ce</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">ftriaxon</span>
| style="width:127.15pt;" width="170" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-font-width:105%">1x2g <span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span></span>
| style="width:190.2pt;" width="254" valign="top" |Infusionsende 30 min  vor Schnitt
| style="width:128.8pt;" width="172" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif">> 8 h OP- <span style="letter-spacing:-.1pt">D</span><span style="letter-spacing:-.05pt">auer</span></span>
|- style="mso-yfti-irow:2"
| style="width:139.65pt;" width="186" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">Fluo</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt">r</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">c</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt">hinolon</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:.4pt">  </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.1pt">Gr</span><span style="font-size:10.0pt;font-family:
  &quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt">uppe</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:.45pt">  </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif">2</span>
| style="width:145.4pt;" width="194" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt">C</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">iproflox</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt">aci</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">n</span>
| style="width:127.15pt;" width="170" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-font-width:105%">1 x 500<span style="letter-spacing:-.05pt">m</span><span style="letter-spacing:-.1pt">g</span> <span style="letter-spacing:-.05pt">p.</span><span style="letter-spacing:-.1pt">o</span><span style="letter-spacing:-.05pt">.</span></span>
 
<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-font-width:
  105%">1 x 400mg i.v.</span>
| style="width:190.2pt;" width="254" valign="top" |120 min vor Schnitt<sup>1)</sup>
 
Infusionsende 30 min  vor Schnitt, Infusionsdauer 60 min
| style="width:128.8pt;" width="172" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-font-width:105%">><span style="letter-spacing:-1.2pt"> </span>8<span style="letter-spacing:-1.2pt"> </span>h<span style="letter-spacing:-1.15pt"> </span><span style="letter-spacing:-.1pt">OP-Daue</span><span style="letter-spacing:-.05pt">r</span></span>
|- style="mso-yfti-irow:3"
| style="width:139.65pt;" width="186" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">Fluo</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt">r</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">c</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt">hinolon</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:.4pt">  </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.1pt">Gr</span><span style="font-size:10.0pt;font-family:
  &quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt">uppe</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:.45pt">  </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif">3</span>
| style="width:145.4pt;" width="194" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt">Lev</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">oflox</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt">aci</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">n</span>
| style="width:127.15pt;" width="170" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-font-width:105%">1 x 500<span style="letter-spacing:-.05pt">m</span><span style="letter-spacing:-.1pt">g</span> <span style="letter-spacing:-.05pt">p.</span><span style="letter-spacing:-.1pt">o</span><span style="letter-spacing:-.05pt">.</span></span>
| style="width:190.2pt;" width="254" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-font-width:105%">120<span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.05pt">min</span></span> vor Schnitt<sup>1)</sup>
| style="width:128.8pt;" width="172" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif">>12<span style="letter-spacing:
  -.4pt"> </span>h<span style="letter-spacing:-.35pt"> </span><span style="letter-spacing:-.1pt">OP-D</span><span style="letter-spacing:-.05pt">auer</span></span>
|- style="mso-yfti-irow:4"
| style="width:139.65pt;" width="186" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">Gly</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt">kopetid</span>
| style="width:145.4pt;" width="194" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt">Vanco</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">m</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt">y</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">cin  <sup>3)</sup></span>
| style="width:127.15pt;" width="170" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif">1<span style="letter-spacing:.35pt">  </span>x<span style="letter-spacing:.35pt"> </span>1g<span style="letter-spacing:
  .4pt"> </span><span style="letter-spacing:-.2pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span></span>
| style="width:190.2pt;" width="254" valign="top" |Infusionsende 30 min vor Schnitt, Infusionsdauer  >60 min<sup>3)</sup>
| style="width:128.8pt;" width="172" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-font-width:105%">><span style="letter-spacing:-1.2pt"> </span>12<span style="letter-spacing:-1.2pt"> </span>h<span style="letter-spacing:-1.2pt"> </span><span style="letter-spacing:-.1pt">OP-Daue</span><span style="letter-spacing:-.05pt">r</span></span>
|- style="mso-yfti-irow:5"
| style="width:139.65pt;" width="186" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt;mso-font-width:
  105%">F</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.1pt;mso-font-width:105%">olat-</span><span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt;mso-font-width:
  105%">An</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.1pt;mso-font-width:105%">t</span><span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt;mso-font-width:
  105%">ago</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.1pt;mso-font-width:105%">nist</span>
| style="width:145.4pt;" width="194" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt">Co</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">trimox</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt">az</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">ol</span>
| style="width:127.15pt;" width="170" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-font-width:105%">1 x 960<span style="letter-spacing:-.05pt">m</span><span style="letter-spacing:-.1pt">g</span> <span style="letter-spacing:-.05pt">p.</span><span style="letter-spacing:-.1pt">o</span><span style="letter-spacing:-.05pt">.</span></span>
| style="width:190.2pt;" width="254" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-font-width:105%">120<span style="letter-spacing:.3pt"> </span><span style="letter-spacing:-.05pt">min</span></span> vor Schnitt<sup>1)</sup>
| style="width:128.8pt;" width="172" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-font-width:105%">><span style="letter-spacing:-1.2pt"> </span>12<span style="letter-spacing:-1.2pt"> </span>h<span style="letter-spacing:-1.2pt"> </span><span style="letter-spacing:-.1pt">OP-Daue</span><span style="letter-spacing:-.05pt">r</span></span>
|- style="mso-yfti-irow:6"
| style="width:139.65pt;" width="186" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">L</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt">i</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">ncos</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt">amid</span>
| style="width:145.4pt;" width="194" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">Cli</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt">ndam</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">y</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt">cin</span>
| style="width:127.15pt;" width="170" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-font-width:105%">1 x 600<span style="letter-spacing:-.05pt">m</span><span style="letter-spacing:-.1pt">g</span> <span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span></span>
| style="width:190.2pt;" width="254" valign="top" |Infusionsende 30 min vor Schnitt
| style="width:128.8pt;" width="172" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif">> 6 h OP- <span style="letter-spacing:-.1pt">D</span><span style="letter-spacing:-.05pt">auer</span></span>
|- style="mso-yfti-irow:7;mso-yfti-lastrow:yes"
| style="width:139.65pt;" width="186" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-font-width:
  105%">Nitroimid</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
  letter-spacing:-.1pt;mso-font-width:105%">az</span><span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-font-width:
  105%">ol</span>
| style="width:145.4pt;" width="194" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt">Met</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">ronid</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.15pt">azo</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt">l</span>
| style="width:127.15pt;" width="170" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-font-width:105%">1 x 500<span style="letter-spacing:-.05pt">m</span><span style="letter-spacing:-.1pt">g</span> <span style="letter-spacing:-.25pt">i.</span><span style="letter-spacing:-.3pt">v</span><span style="letter-spacing:-.25pt">.</span></span>
| style="width:190.2pt;" width="254" valign="top" |Infusionsende 30 min vor Schnitt
| style="width:128.8pt;" width="172" valign="top" |<span style="font-size:
  10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-font-width:105%">><span style="letter-spacing:-1.2pt"> </span>8<span style="letter-spacing:-1.2pt"> </span>h<span style="letter-spacing:-1.15pt"> </span><span style="letter-spacing:-.1pt">OP-Daue</span><span style="letter-spacing:-.05pt">r</span></span>
|}
<sup>1)</sup> Maximaler Serumspiegel <span style="letter-spacing:.05pt">bei</span> <span style="letter-spacing:.05pt">normaler</span> enteraler <span style="letter-spacing:.05pt">Resorption</span>
 
<sup>2)</sup> „Imipenem 1g“ entspricht Imipenem 1g + Cilastatin 1g (= 2x 1Ampulle à 0,5g Imipenem + 0,5g Cilastatin)
 
<sup>3)</sup> Infusionsdauer > 1 h, ansonsten <span style="letter-spacing:.05pt">Gefahr</span> von „Red-Man-Syndrom“ <span style="letter-spacing:-.05pt">(Hautrötung</span> <span style="letter-spacing:
.05pt">u.</span> <span style="letter-spacing:-.05pt">Schwellung</span> im <span style="letter-spacing:.05pt">Kopf-Hals-Bereich,</span> die <span style="letter-spacing:.05pt">wie</span> eine <span style="letter-spacing:.05pt">Allergie</span> imponieren kann)
 
<sup>4)</sup> In Abhängigkeit von <span style="letter-spacing:
.05pt">der</span> Halbwertszeit <span style="letter-spacing:.05pt">bei</span> <span style="letter-spacing:.05pt">normaler</span> <span style="letter-spacing:.05pt">Nierenfunktion</span>
 
<span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:.05pt;mso-ansi-language:EN-US">Angaben Halbwertzeiten: </span>''<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;
mso-ansi-language:EN-US">Mandell,</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-ansi-language:
EN-US"> <span style="letter-spacing:-.05pt">Douglas</span> and <span style="letter-spacing:.05pt">Bennetts:</span> <span style="letter-spacing:-.05pt">Principles</span> and Practise <span style="letter-spacing:-.1pt">of</span> <span style="letter-spacing:.05pt">Infectious</span><span style="letter-spacing:3.4pt"> </span>Disease.</span> Elsevier <span style="letter-spacing:-.05pt">Inc.</span> <span style="letter-spacing:-.2pt">2009,</span> Fachinformationen''
 
'''Literatur Seite 2-3:'''
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">      </span></span>Perioperative Antibiotika-Prophylaxe: <span style="letter-spacing:-.05pt">Empfehlungen</span> <span style="letter-spacing:.05pt">einer</span> <span style="letter-spacing:
.05pt">Expertenkommission</span> <span style="letter-spacing:.05pt">der</span> <span style="letter-spacing:-.05pt">PEG</span> <span style="letter-spacing:.05pt">für</span> <span style="letter-spacing:.05pt">Chemotherapie</span> <span style="letter-spacing:
-.25pt">e.V.;</span> Wacha H et <span style="letter-spacing:.05pt">al.;</span><span style="letter-spacing:5.3pt"> </span><span style="letter-spacing:.05pt">Chemother</span> J 2010; <span style="letter-spacing:.05pt">19:</span> <span style="letter-spacing:
.1pt">70-84</span>
 
<span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol;mso-ansi-language:EN-US"><span style="mso-list:
Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
letter-spacing:-.1pt;mso-ansi-language:EN-US">Single-</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">versus</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">multiple-dose</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;mso-ansi-language:EN-US">antimicrobial</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">prophylaxis</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">for</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">major</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">surgery:</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;mso-ansi-language:EN-US">a <span style="letter-spacing:-.05pt">systematic</span> <span style="letter-spacing:-.05pt">review.McDonald</span> M et al.; <span style="letter-spacing:-.1pt">Aust</span> N Z J <span style="letter-spacing:-.15pt">Surg</span> <span style="letter-spacing:-.05pt">1999;</span> <span style="letter-spacing:.05pt">69:68-69.</span></span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">      </span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-ansi-language:
EN-US">Antibiotic prophylaxis and the <span style="letter-spacing:.05pt">risk</span> of Clostridium <span style="letter-spacing:.05pt">difficile-associated</span> <span style="letter-spacing:.05pt">diarrhoea.</span></span> Harbarth S et <span style="letter-spacing:.05pt">al.;</span> J Hosp <span style="letter-spacing:
-.05pt">Inf</span> <span style="letter-spacing:.05pt">2001;</span> <span style="letter-spacing:.05pt">48:93-97.</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">      </span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-ansi-language:
EN-US">Cost and morbidity associated <span style="letter-spacing:-.05pt">with</span> antibiotic prophylaxis in the ICU.<span style="letter-spacing:2.0pt"> </span></span>Namias N et <span style="letter-spacing:.05pt">al.;</span> J Am Coll <span style="letter-spacing:
-.15pt">Surg.</span> <span style="letter-spacing:.05pt">1999;</span> <span style="letter-spacing:.05pt">188:225-230.</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">      </span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:.05pt;
mso-ansi-language:EN-US">Rapid</span> <span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;mso-ansi-language:EN-US"><span style="letter-spacing:
.05pt">emergence</span> of <span style="letter-spacing:-.05pt">resistant</span> coagulase-negativ staphylococci on skin <span style="letter-spacing:.05pt">after</span> antibiotic prophylaxis.</span> Terpstra S et <span style="letter-spacing:.05pt">al.;</span> J Hosp <span style="letter-spacing:
-.05pt">Inf</span> <span style="letter-spacing:.05pt">1999;</span> <span style="letter-spacing:.05pt">43:195-202</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">      </span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:.05pt;
mso-ansi-language:EN-US">The</span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;
mso-ansi-language:EN-US">timing</span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;
mso-ansi-language:EN-US">of</span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;
mso-ansi-language:EN-US">prophylactic</span><span style="font-size:10.0pt;
font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
letter-spacing:-.1pt;mso-ansi-language:EN-US">administration</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">of</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">antibiotics</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">and</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">the</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">risk</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">of</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;mso-ansi-language:EN-US">surgical</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">wound</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">infection.</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span>Classen DC et al.; N <span style="letter-spacing:-.15pt">Eng</span> J Med <span style="letter-spacing:-.1pt">1992;</span><span style="letter-spacing:4.65pt"> </span><span style="letter-spacing:-.05pt">326:281-286;</span>
 
<span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol;mso-ansi-language:EN-US"><span style="mso-list:
Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
letter-spacing:.05pt;mso-ansi-language:EN-US">The</span><span style="font-size:
10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;mso-ansi-language:
EN-US"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
letter-spacing:-.15pt;mso-ansi-language:EN-US">Timing</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">of</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;mso-ansi-language:EN-US">Surgical</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;mso-ansi-language:EN-US">Antimicrobial</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">Prophylaxis.</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">Weber</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:.05pt;mso-ansi-language:EN-US">WP</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;mso-ansi-language:EN-US">et al.; <span style="letter-spacing:-.05pt">Annals</span> <span style="letter-spacing:-.05pt">of</span> <span style="letter-spacing:-.1pt">Surgery</span> <span style="letter-spacing:.05pt">2008;</span> <span style="letter-spacing:-.1pt">247:918-926</span></span>
 
<span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol;mso-ansi-language:EN-US"><span style="mso-list:
Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span></span><span style="color: black">Guideline for the Prevention of Surgical Site Infection, 2017. Centers for Disease Control and Prevention; JAMA Surg. 2017;152 (8):784-791.</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">      </span></span><span style="color: black">American College of Surgeons and Surgical Infection Society: Surgical Site Infection Guidelines, 2016 Update. </span>J Am Coll Surg. 2017 Jan; 224 (1):59-7
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">      </span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-ansi-language:
EN-US">Evidence-based <span style="letter-spacing:-.05pt">recommendations</span> <span style="letter-spacing:-.05pt">for</span> <span style="letter-spacing:-.05pt">perioperative</span> <span style="letter-spacing:-.1pt">antibiotic</span> <span style="letter-spacing:-.05pt">prophylaxis.</span></span> Ebner W et al.; <span style="letter-spacing:-.1pt">Chirurg</span> <span style="letter-spacing:.1pt">2000;</span> <span style="letter-spacing:-.05pt">71:912-917</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">      </span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;
mso-ansi-language:EN-US">Clinical</span><span style="font-size:10.0pt;
font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
letter-spacing:-.05pt;mso-ansi-language:EN-US">practice</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">guidelines</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">for</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;mso-ansi-language:EN-US">antimicrobial</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">prophylaxis</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.05pt;mso-ansi-language:EN-US">in</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:
&quot;Verdana&quot;,sans-serif;letter-spacing:-.1pt;mso-ansi-language:EN-US">surgery.</span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;letter-spacing:-.2pt;
mso-ansi-language:EN-US"> </span>Bratzler et <span style="letter-spacing:-.05pt">al.</span> <span style="letter-spacing:-.05pt">Am</span> J <span style="letter-spacing:-.1pt">Health</span> <span style="letter-spacing:-.1pt">Syst</span> <span style="letter-spacing:-.05pt">Pharm.</span> <span style="letter-spacing:-.1pt">2013</span> <span style="letter-spacing:-.1pt">Feb</span> 1;70(3):195-283
 
<span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol;mso-ansi-language:EN-US"><span style="mso-list:
Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
mso-ansi-language:EN-US">WHO: Global guidelines on the prevention for surgical site infections, November 2016</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">      </span></span>Aktualisierte Empfehlungen zur perioperativen Antibiotikaprophylaxe in der Schweiz, 2015
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">      </span></span>Perioperative Antibiotikaprophylaxe: ein Update; Maier, S. et al: Krankenhaushygiene up2date 10/2015
 
<span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol;mso-ansi-language:EN-US"><span style="mso-list:
Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
mso-ansi-language:EN-US">Timing of surgical antimicrobial prophylaxis: a phase 3 randomised controlled trial.</span> Weber W.P. et al.<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;mso-ansi-language:
EN-US">; Lancet Infect Dis 2017; 17: 605–14</span>
 
<span style="font-size:10.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol;mso-ansi-language:EN-US"><span style="mso-list:
Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">     </span></span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
mso-ansi-language:EN-US">Is It Time to Refine? An Exploration and Simulation of Optimal Antibiotic Timing in General Surgery.</span> Koch C.G. et al.; J Am Coll Surg 2013; 217:628-635
 
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*<span style="font-size:10.0pt;font-family:      &quot;Verdana&quot;,sans-serif;mso-ansi-language:EN-US">Antibiotic prophylaxis using    third generation cephalosporins can reduce the risk of early rebleeding in    the first acute gastroesophageal variceal hemorrhage: a prospective    randomized study. </span>Jun CH et al.; Korean Med Sci 2006; 21:883-890
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*<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;      mso-ansi-language:EN-US">Antibiotics to reduce post-tonsillectomy morbidity.    </span>Dhiwakar    M et al.; Cochrane Database Syst Rev 2010; 7:CD005607
*<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;      mso-ansi-language:EN-US">Antibiotic prophylaxis in clean and    clean-contaminated ear surgery. </span>Verschuur HP et al.; Cochrane    Database Syst Rev 2004; 3:CD003996.
*<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;      mso-ansi-language:EN-US">Antibiotic prophylaxis in uncontaminated neck    dissection. Man LX et al.; Laryngoscope 2011; 121:1473-1477.</span>
*<span style="font-size:10.0pt;font-family:      &quot;Verdana&quot;,sans-serif;mso-ansi-language:EN-US">Antibiotic prophylaxis for    surgery for proximal femoral and other closed long bone fractures. </span>Gillespie    WJ, Walenkamp GH.; Cochrane Database Syst Rev 2010; 17:CD000244.
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*<span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;      mso-ansi-language:EN-US">Prophylactic antibiotics in orthopaedic surgery.    Prokuski L.; J Am Acad Orthop Surg 2008; 16:283-93.</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
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<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span>Perioperative Antibiotikaprophylaxe in der Dermatochirurgie: update 2009. Mühlstädt M et al.; Hautarzt 2009; 60:546-549;
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
mso-ansi-language:EN-US">Antibiotic prophylaxis in dermatologic surgery: advisory statement 2008.</span> Wright TI et al.; J Am Acad Dermatol 2008, 59:464-473
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
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mso-ansi-language:EN-US"> </span>Am J of Urology 2008; 179:1379-1390
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
mso-ansi-language:EN-US">Antibiotic prophylaxis in urologic procedures: a systematic review.</span> Bootsma AM et al.; Eur Urol 2008; 54:1270-86
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
mso-fareast-font-family:&quot;Book Antiqua&quot;;mso-bidi-font-family:&quot;Book Antiqua&quot;;
mso-ansi-language:EN-US">Prospective, randomized, multicentric, open, comparative study on the efficacy of a prophylactic single dose of 500 mg levofloxacin versus 1920 mg trimethoprim/sulfamethoxazole versus a control group in patients undergoing TUR of the prostate. </span>Wagenlehner FM et al. Working Group „Urological Infections“ of German Society of Urology; Eur Urol 2005; 47:549-556
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
mso-ansi-language:EN-US">Timing of administration of prophylactic antibiotics for caesarean section: a systematic review and meta-analysis.</span> Baaqeel H, Baaqeel R. BJOG 2012;120:661–669
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
mso-ansi-language:EN-US">Effectiveness of a bundled intervention of decolonization and prophylaxis to decrease Gram positive surgical site infections after cardiac or orthopedic surgery: systematic review and meta-analysis.</span> Schweizer et al. BMJ 2013;346: f2743
 
<span style="font-size:10.0pt;
font-family:Symbol;mso-fareast-font-family:Symbol;mso-bidi-font-family:Symbol;
mso-ansi-language:EN-US"><span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
mso-ansi-language:EN-US">Mupirocin ointment for preventing Staphylococcus aureus infections in nasal carriers. van Rijen et al, Cochrane Database Syst Rev. 2008 Oct 8;</span>
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span>Resistenzstatistik des HELIOS-Konzerns 2013
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span>Empfehlungen zur Prävention und Kontrolle von Methicillinresistenten Staphylococcus aureus-Stämmen (MRSA) in medizinischen und pflegerischen Einrichtungen. Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) beim Robert Koch-Institut. Bundesgesundheitsbl 2014 57:696–73
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span><span style="font-size:10.0pt;font-family:&quot;Verdana&quot;,sans-serif;
mso-ansi-language:EN-US">Clinical practice guidelines for antimicrobial prophylaxis in surgery.</span> Bratzler et al. Am J Health-Syst Pharm. 2013; 70:195-283
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span>Perioperative Antibiotika-Prophylaxe: Empfehlungen einer Expertenkommission der PEG für Chemotherapie e.V.; Wacha H et al.; Chemother J 2010; 19:70-84
 
<span style="mso-list:Ignore">· <span style="font:7.0pt &quot;Times New Roman&quot;">       </span></span>Perioperative Antibiotika-Prophylaxe bei Haut- und Weichteileingriffen. Schultze, T. et al.; Hautarzt 2014; 65: 32-3

Latest revision as of 15:43, 16 January 2026

Die perioperative Antibiotikaprophylaxe (PAP) wird kurzzeitig bei bestimmten Eingriffen eingesetzt mit dem Ziel die postoperativen Infektionskomplikationen zu verhindern oder zu reduzieren. Es handelt sich um eine Prophylaxe, keine Therapie. Bei Vorliegen einer Infektion muss die Antibiotikagabe als Therapie weitergeführt werden und eine erneute perioperative mikrobiologische Diagnostik durchgeführt werden.

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