DGI:Opportunistische Infektionen/Kryptokokkose/Therapie/Kalkulierte Therapie: Difference between revisions
imported>Brinkery (Die Seite wurde neu angelegt: „=== Kalkulierte Therapie ===“) |
imported>Brinkery No edit summary |
||
| Line 1: | Line 1: | ||
=== Kalkulierte Therapie === | === Kalkulierte Therapie === | ||
{| class="wikitable sortable bs-exportable MsoTableGrid" border="1" cellspacing="0" cellpadding="0" align="left" width="775" style="border-collapse:collapse;mso-table-layout-alt:fixed;" | |||
|+ | |||
| style="width:99.0pt;" width="132" |<span style="font-size:8.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font: | |||
minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">'''Klinische Situation'''</span> | |||
| style="width:92.15pt;" width="123" |<span style="font-size: | |||
8.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin; | |||
mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">'''Präferenz'''</span> | |||
| style="width:106.5pt;" width="142" |<span style="font-size: | |||
8.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin; | |||
mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">'''Substanz'''</span> | |||
| style="width:99.25pt;" width="132" |<span style="font-size: | |||
8.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin; | |||
mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">'''Dosierung'''</span> | |||
| style="width:42.5pt;" width="57" |<span style="font-size: | |||
8.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin; | |||
mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">'''Dauer'''</span> | |||
| style="width:5.0cm;" width="189" |<span style="font-size: | |||
8.0pt;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin; | |||
mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">'''Kommentar'''</span> | |||
|- style="height:167.15ptpx;" | |||
| rowspan="4" style="width:99.0pt;" width="132" |<span style="font-size:8.0pt;line-height: | |||
150%;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin; | |||
mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Induktionstherapie </span> | |||
| rowspan="2" style="width:92.15pt;" width="123" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Therapie der 1. Wahl</span> | |||
| style="width:106.5pt;" width="142" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Liposomales</span> [https://abbuch.uk-koeln.de/index.php/Antimykotika#Amphotericin_B.2C_liposomales <span style="color: windowtext">Amphotericin B</span>] | |||
| style="width:99.25pt;" width="132" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">1 x 3-4 mg/kg i.v./pro Tag</span> | |||
| rowspan="2" style="width:42.5pt;" width="57" |'''<span style="font-size:8.0pt;line-height:150%;mso-no-proof:yes">≥ </span>'''2 Wochen | |||
| style="width:5.0cm;" width="189" |<span style="font-size: | |||
8.0pt;line-height:150%;font-family:"Calibri",sans-serif;mso-ascii-theme-font: | |||
minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Cave: Liposmales Amphotericin B engmaschige Kontrollen von Kalium, Magnesium, Kreatinin und Hämoglobin.</span> | |||
<span style="font-size: | |||
8.0pt;line-height:150%;font-family:"Calibri",sans-serif;mso-ascii-theme-font: | |||
minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Falls Flucytosin nicht mit <span style="mso-spacerun:yes"> </span>liposomalem</span> [https://abbuch.uk-koeln.de/index.php/Antimykotika#Amphotericin_B.2C_liposomales <span style="color: windowtext">Amphotericin B</span>] <span style="font-size:8.0pt;line-height:150%; | |||
font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-fareast-font-family: | |||
Calibri;mso-fareast-theme-font:minor-latin;mso-hansi-theme-font:minor-latin; | |||
mso-bidi-font-family:Arial;mso-bidi-theme-font:minor-bidi;mso-fareast-language: | |||
EN-US;mso-no-proof:yes">kombiniert werden kann, ist auch eine Monotherapie mit <span style="mso-spacerun:yes"> </span>liposomalem</span> [https://abbuch.uk-koeln.de/index.php/Antimykotika#Amphotericin_B.2C_liposomales <span style="color: windowtext">Amphotericin B</span>] <span style="font-size:8.0pt;line-height:150%; | |||
font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin;mso-fareast-font-family: | |||
Calibri;mso-fareast-theme-font:minor-latin;mso-hansi-theme-font:minor-latin; | |||
mso-bidi-font-family:Arial;mso-bidi-theme-font:minor-bidi;mso-fareast-language: | |||
EN-US;mso-no-proof:yes">über 4-6 Wochen oder eine Kombinationstherapie mit Fluconazol möglich</span><sup><span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">24.</span></sup><span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">.</span> | |||
|- style="height:64.75ptpx;" | |||
| style="width:106.5pt;" width="142" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Flucytosin</span> | |||
| style="width:99.25pt;" width="132" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">100 mg/kg aufgteilt in 4 Einzeldosen pro Tag</span> | |||
| style="width:5.0cm;" width="189" |<span style="font-size: | |||
8.0pt;line-height:150%;font-family:"Calibri",sans-serif;mso-ascii-theme-font: | |||
minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Cave: engmaschige Blutbildkontrollen (Panzytopenie).</span> | |||
<span style="font-size: | |||
8.0pt;line-height:150%;font-family:"Calibri",sans-serif;mso-ascii-theme-font: | |||
minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Keine Anwendung von Brivudin bei Flucytosin.</span> | |||
|- style="height:72.0ptpx;" | |||
| rowspan="2" style="width:92.15pt;" width="123" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Therapie der 2. Wahl</span> | |||
<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">(WHO-Schema<sup>20</sup>)</span> | |||
| style="width:106.5pt;" width="142" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Fluconazol</span> | |||
| style="width:99.25pt;" width="132" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">1200 mg/Tag*</span> | |||
| rowspan="2" style="width:42.5pt;" width="57" |'''<span style="font-size:8.0pt;line-height:150%;mso-no-proof:yes">≥ </span>'''2 <span style="mso-spacerun:yes"> </span>Wochen | |||
| style="width:5.0cm;" width="189" |<span style="font-size: | |||
8.0pt;line-height:150%;font-family:"Calibri",sans-serif;mso-ascii-theme-font: | |||
minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">*Gemäß der IDSA/CDC Leitlinie</span><sup><span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">3</span></sup> <span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">kann auch eine geringer Fluconazoldosis (400-800mg/Tag) in Kombination mit Flucytosin gewählt werden.</span> | |||
<span style="font-size: | |||
8.0pt;line-height:150%;font-family:"Calibri",sans-serif;mso-ascii-theme-font: | |||
minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Falls Flucytosin nicht mit Fluconazol kombiniert werden kann, ist<span style="mso-spacerun:yes"> </span> Monotherapie mit Fluconazol 1200mg/Tag möglich</span><sup><span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">3</span></sup><span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">.</span> | |||
|- style="height:72.0ptpx;" | |||
| style="width:106.5pt;" width="142" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Flucytosin</span> | |||
| style="width:99.25pt;" width="132" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">100 mg/kg aufgteilt in 4 Einzeldosen pro Tag</span> | |||
| style="width:5.0cm;" width="189" |<span style="font-size: | |||
8.0pt;line-height:150%;font-family:"Calibri",sans-serif;mso-ascii-theme-font: | |||
minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Cave: engmaschige Blutbildkontrollen (Panzytopenie). <span style="mso-spacerun:yes"> </span></span> | |||
<span style="font-size: | |||
8.0pt;line-height:150%;font-family:"Calibri",sans-serif;mso-ascii-theme-font: | |||
minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Keine Anwendung von Brivudin bei Flucytosin.</span> | |||
|- style="height:48.6ptpx;" | |||
| style="width:99.0pt;" width="132" |<span style="font-size:8.0pt;line-height: | |||
150%;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin; | |||
mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Konsolidierungstherapie </span> | |||
| style="width:92.15pt;" width="123" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Therapie der 1. Wahl<sup>20</sup></span> | |||
| style="width:106.5pt;" width="142" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Fluconazol</span> | |||
| style="width:99.25pt;" width="132" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">800 mg/Tag</span> | |||
| style="width:42.5pt;" width="57" |'''<span style="font-size:8.0pt;line-height:150%;mso-no-proof:yes">≥ </span>'''<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">8 Wochen</span> | |||
| style="width:5.0cm;" width="189" | | |||
|- style="height:55.7ptpx;" | |||
| style="width:99.0pt;" width="132" |<span style="font-size:8.0pt;line-height: | |||
150%;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin; | |||
mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Konsolidierungstherapie </span> | |||
| style="width:92.15pt;" width="123" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Therapie der 2. Wahl<sup>17</sup></span> | |||
| style="width:106.5pt;" width="142" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Itraconazol</span> | |||
| style="width:99.25pt;" width="132" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">200mg 2 x tgl</span> | |||
| style="width:42.5pt;" width="57" |'''<span style="font-size:8.0pt;line-height:150%;mso-no-proof:yes">≥ </span>'''<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">8 Wochen</span> | |||
| style="width:5.0cm;" width="189" |<span style="font-size: | |||
8.0pt;line-height:150%;font-family:"Calibri",sans-serif;mso-ascii-theme-font: | |||
minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Bei Itraconazol sollte ein therapeutisches Drugmonitoring (TDM) durchgeführt werden</span><sup><span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">24</span></sup><span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">.</span> | |||
|- style="height:72.0ptpx;" | |||
| style="width:99.0pt;" width="132" |<span style="font-size:8.0pt;line-height: | |||
150%;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin; | |||
mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Erhaltungstherapie (Sekundärprophylaxe)</span> | |||
| style="width:92.15pt;" width="123" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Therapie der 1. Wahl</span> | |||
| style="width:106.5pt;" width="142" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Fluconazol</span> | |||
| style="width:99.25pt;" width="132" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">200 mg/Tag</span> | |||
| style="width:42.5pt;" width="57" |'''<span style="font-size:8.0pt;line-height:150%;mso-no-proof:yes">≥ </span>'''<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">12 Monte</span> | |||
| style="width:5.0cm;" width="189" | | |||
|- style="height:72.0ptpx;" | |||
| style="width:99.0pt;" width="132" |<span style="font-size:8.0pt;line-height: | |||
150%;font-family:"Calibri",sans-serif;mso-ascii-theme-font:minor-latin; | |||
mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Erhaltungstherapie (Sekundärprophylaxe)</span> | |||
| style="width:92.15pt;" width="123" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Therapie der 2. Wahl<sup>3,17</sup></span> | |||
| style="width:106.5pt;" width="142" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Itraconazol</span> | |||
| style="width:99.25pt;" width="132" |<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">200mg 2 x tgl</span> | |||
| style="width:42.5pt;" width="57" |'''<span style="font-size:8.0pt;line-height:150%;mso-no-proof:yes">≥ </span>'''<span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">12 Monte</span> | |||
| style="width:5.0cm;" width="189" |<span style="font-size: | |||
8.0pt;line-height:150%;font-family:"Calibri",sans-serif;mso-ascii-theme-font: | |||
minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin; | |||
mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial;mso-bidi-theme-font: | |||
minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">Bei Itraconazol sollte ein therapeutisches Drugmonitoring (TDM) durchgeführt werden</span><sup><span style="font-size:8.0pt;line-height:150%;font-family:"Calibri",sans-serif; | |||
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font: | |||
minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:Arial; | |||
mso-bidi-theme-font:minor-bidi;mso-fareast-language:EN-US;mso-no-proof:yes">24.</span></sup> | |||
|} | |||
<br /> | |||
Revision as of 14:34, 27 September 2021
Kalkulierte Therapie
| Klinische Situation | Präferenz | Substanz | Dosierung | Dauer | Kommentar |
| Induktionstherapie | Therapie der 1. Wahl | Liposomales Amphotericin B | 1 x 3-4 mg/kg i.v./pro Tag | ≥ 2 Wochen | Cave: Liposmales Amphotericin B engmaschige Kontrollen von Kalium, Magnesium, Kreatinin und Hämoglobin.
Falls Flucytosin nicht mit liposomalem Amphotericin B kombiniert werden kann, ist auch eine Monotherapie mit liposomalem Amphotericin B über 4-6 Wochen oder eine Kombinationstherapie mit Fluconazol möglich24.. |
| Flucytosin | 100 mg/kg aufgteilt in 4 Einzeldosen pro Tag | Cave: engmaschige Blutbildkontrollen (Panzytopenie).
Keine Anwendung von Brivudin bei Flucytosin. | |||
| Therapie der 2. Wahl
(WHO-Schema20) |
Fluconazol | 1200 mg/Tag* | ≥ 2 Wochen | *Gemäß der IDSA/CDC Leitlinie3 kann auch eine geringer Fluconazoldosis (400-800mg/Tag) in Kombination mit Flucytosin gewählt werden.
Falls Flucytosin nicht mit Fluconazol kombiniert werden kann, ist Monotherapie mit Fluconazol 1200mg/Tag möglich3. | |
| Flucytosin | 100 mg/kg aufgteilt in 4 Einzeldosen pro Tag | Cave: engmaschige Blutbildkontrollen (Panzytopenie).
Keine Anwendung von Brivudin bei Flucytosin. | |||
| Konsolidierungstherapie | Therapie der 1. Wahl20 | Fluconazol | 800 mg/Tag | ≥ 8 Wochen | |
| Konsolidierungstherapie | Therapie der 2. Wahl17 | Itraconazol | 200mg 2 x tgl | ≥ 8 Wochen | Bei Itraconazol sollte ein therapeutisches Drugmonitoring (TDM) durchgeführt werden24. |
| Erhaltungstherapie (Sekundärprophylaxe) | Therapie der 1. Wahl | Fluconazol | 200 mg/Tag | ≥ 12 Monte | |
| Erhaltungstherapie (Sekundärprophylaxe) | Therapie der 2. Wahl3,17 | Itraconazol | 200mg 2 x tgl | ≥ 12 Monte | Bei Itraconazol sollte ein therapeutisches Drugmonitoring (TDM) durchgeführt werden24. |