DGI:ZNS-Infektionen/Anmerkung der Redaktion

From Infektiopedia
Revision as of 15:26, 12 November 2020 by imported>Brinkery

Anmerkung der Redaktion


1.       Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, Moreno R, Lipman J, Gomersall C, Sakr Y, Reinhart K, EPIC II Group of Investigators. International study of the prevalence and outcomes of infection in intensive care units. JAMA 2009; 2;302(21):2323-9

2.       Kumta N, Roberts JA, Lipman J et al. Antibiotic distribution into cerebrospinal fluid: Can dosing safely account for drug and disease factors in the treatment of ventriculostomy-associated infections? Clin Pharmacokinet 2018; 57: 439–454

3.       Bassmann U, Roehr AC, Frey OR, Vetter-Kerkhoff C, Thon N, Hope W, Briegel J, Huge V. Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study. Crit Care 2016; 20: 343

4.       Conen A, Fux CA, Vajkoczy P, Trampuz A. Management of infections associated with neurosurgical implanted devices. Expert Rev Anti Infect Ther 2017;15(3): 241-255

5.      Nau R et al. S1-Leitlinie Hirnabszess. 2016. In: Deutsche Gesellschaft für Neurologie, Hrsg. Leitlinien für Diagnostik und Therapie in der Neurologie. Online: www.dgn.org/leitlinien

6.       Tunkel AR, Hasbun R, Bhimraj A, Byers K, Kaplan SL, Scheld WM, van de Beek D, Bleck TB, Garton HJL, Zunt JR. 2017 Infectious Diseases Society of America’s Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis. Clin Infect Dis 2017; 64: e34–e65

7.      Kalkulierte parenterale Initialtherapie bakterieller Erkrankungen bei Erwachsenen - Update 2018. https://www.awmf.org/leitlinien/detail/ll/082-006.html


1.         Schaberg, T., et al., [Tuberculosis Guideline for Adults - Guideline for Diagnosis and Treatment of Tuberculosis including LTBI Testing and Treatment of the German Central Committee (DZK) and the German Respiratory Society (DGP)]. Pneumologie, 2017. 71(6): p. 325-397.

2.         Wilkinson, R.J., et al., Tuberculous meningitis. Nat Rev Neurol, 2017. 13(10): p. 581-598.

3.         Ducomble, T., et al., The burden of extrapulmonary and meningitis tuberculosis: an investigation of national surveillance data, Germany, 2002 to 2009. Euro Surveill, 2013. 18(12).

4.         in Tuberculosis: Clinical Diagnosis and Management of Tuberculosis, and Measures for Its Prevention and Control. 2011: London.

5.         Thwaites, G., et al., British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children. J Infect, 2009. 59(3): p. 167-87.

6.         Marais, S., et al., Frequency, severity, and prediction of tuberculous meningitis immune reconstitution inflammatory syndrome. Clin Infect Dis, 2013. 56(3): p. 450-60.

7.         Chin, J.H., Tuberculous meningitis: Diagnostic and therapeutic challenges. Neurol Clin Pract, 2014. 4(3): p. 199-205.

8.         Marais, S., et al., Tuberculous meningitis: a uniform case definition for use in clinical research. Lancet Infect Dis, 2010. 10(11): p. 803-12.

9.         Amagon, K.I., O. Awodele, and A.J. Akindele, Methionine and vitamin B-complex ameliorate antitubercular drugs-induced toxicity in exposed patients. Pharmacol Res Perspect, 2017. 5(5).

10.       Prasad, K. and M.B. Singh, Corticosteroids for managing tuberculous meningitis. Cochrane Database Syst Rev, 2008(1): p. CD002244.

11.       Thwaites, G.E., et al., Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. N Engl J Med, 2004. 351(17): p. 1741-51.


1.         Darlow, C.A., et al., Microbial aetiology of brain abscess in a UK cohort: Prominent role of Streptococcus intermedius. J Infect, 2020. 80(6): p. 623-629.

2.         R, N., S1-Leitlinie Hirnabszess. . In: Deutsche Gesellschaft für Neurologie, Hrsg. Leitlinien für Diagnostik und Therapie in der Neurologie. , 2016.

3.         Alvis Miranda, H., et al., Brain abscess: Current management. J Neurosci Rural Pract, 2013. 4(Suppl 1): p. S67-81.

4.         Brouwer, M.C., et al., Brain abscess. N Engl J Med, 2014. 371(5): p. 447-56.

5.         Mishra, A.M., et al., Comparison of the magnetization transfer ratio and fluid-attenuated inversion recovery imaging signal intensity in differentiation of various cystic intracranial mass lesions and its correlation with biological parameters. J Magn Reson Imaging, 2006. 24(1): p. 52-6.

6.         Xu, X.X., et al., Can diffusion-weighted imaging be used to differentiate brain abscess from other ring-enhancing brain lesions? A meta-analysis. Clin Radiol, 2014. 69(9): p. 909-15.

7.         Mishra, A.K., et al., Molecular revolution in the diagnosis of microbial brain abscesses. Eur J Clin Microbiol Infect Dis, 2014. 33(12): p. 2083-93.

8.         Sonneville, R., et al., An update on bacterial brain abscess in immunocompetent patients. Clin Microbiol Infect, 2017. 23(9): p. 614-620.

9.         Sharma, R., K. Mohandas, and R.P. Cooke, Intracranial abscesses: changes in epidemiology and management over five decades in Merseyside. Infection, 2009. 37(1): p. 39-43.


1.            Tunkel AR, Hasbun R, Bhimraj A, Byers K, Kaplan SL, Michael Scheld W, van de Beek D, Bleck TP, Garton HJ, Zunt JR: 2017 Infectious Diseases Society of America's Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis. Clin Infect Dis 2017.

2.            Reyes MM, Munigala S, Church EL, Kulik TB, Keyrouz SG, Zipfel GJ, Warren DK: Comparing External Ventricular Drains-Related Ventriculitis Surveillance Definitions. Infect Control Hosp Epidemiol 2017, 38(5):574-579.

3.            Beer R, Lackner P, Pfausler B, Schmutzhard E: Nosocomial ventriculitis and meningitis in neurocritical care patients. J Neurol 2008, 255(11):1617-1624.

4.            Ambulant erworbene bakterielle (eitrige) Meningoenzephalitis im Erwachsenenalter, AWMF-Registernummer: 030/089 [https://www.awmf.org/leitlinien/detail/ll/030-089.html]

5.            Nau R, Blei C, Eiffert H: Intrathecal Antibacterial and Antifungal Therapies. Clin Microbiol Rev 2020, 33(3).

6.            Karvouniaris M, Brotis AG, Tsiamalou P, Fountas KN: The Role of Intraventricular Antibiotics in the Treatment of Nosocomial Ventriculitis/Meningitis from Gram-Negative Pathogens: A Systematic Review and Meta-Analysis. World Neurosurg 2018, 120:e637-e650.

7.            Nau R, Seele J, Djukic M, Eiffert H: Pharmacokinetics and pharmacodynamics of antibiotics in central nervous system infections. Curr Opin Infect Dis 2018, 31(1):57-68.

8.            Nau R, Sorgel F, Eiffert H: Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections. Clin Microbiol Rev 2010, 23(4):858-883.

9.            Nau R, Sorgel F, Prange HW: Pharmacokinetic optimisation of the treatment of bacterial central nervous system infections. Clin Pharmacokinet 1998, 35(3):223-246.

10.          Mader MM, Czorlich P, Konig C, Fuhrmann V, Kluge S, Westphal M, Grensemann J: Intrathecal penetration of meropenem and vancomycin administered by continuous infusion in patients suffering from ventriculitis-a retrospective analysis. Acta Neurochir (Wien) 2018, 160(11):2099-2105.

11.          Tangden T, Enblad P, Ullberg M, Sjolin J: Neurosurgical gram-negative bacillary ventriculitis and meningitis: a retrospective study evaluating the efficacy of intraventricular gentamicin therapy in 31 consecutive cases. Clin Infect Dis 2011, 52(11):1310-1316.